Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.32 |
| ▸ | CA2 | P00918 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.30 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.30 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708608 | 0.81 | POLB (0.38) | POLBCA1CA2L3MBTL1MAPT | |
| SCHEMBL5552171 | 0.79 | KAT6A (0.40) | POLBCA1CA2LMNAMAPT | |
| SCHEMBL30195988 | 0.78 | ALDH1A1 (0.38) | POLBCA1CA2L3MBTL1MAPT | |
| SCHEMBL28295025 | 0.75 | ALDH1A1 (0.35) | POLBCA1CA2L3MBTL1MAPT | |
| SCHEMBL4602235 | 0.74 | TAS1R3 (0.36) | CA1CA2LMNAALDH1A1KMT2A | |
| SCHEMBL9425246 | 0.74 | MEP1B (0.38) | LMNAALDH1A1KMT2ATSHRMEP1B | |
| SCHEMBL28331355 | 0.74 | L3MBTL1 (0.44) | POLBLMNAL3MBTL1MAPTALDH1A1 | |
| SCHEMBL5663956 | 0.73 | LMNA (0.45) | POLBCA1CA2LMNAMAPT | |
| SCHEMBL28379759 | 0.73 | SMN1; SMN2 (0.40) | L3MBTL1KDM4E | |
| SCHEMBL9691297 | 0.73 | ACHE (0.39) | POLBLMNAMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055288-A1 | ANTIDIABETIC TRICYCLIC COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015051725-A1 | ANTIDIABETIC TRICYCLIC COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2015-04-16 | — | — | WO | disclosed |