Tetramethylkaempferol

Tetramethylkaempferol

SCHEMBL1664159

COc1ccc(-c2oc3cc(OC)cc(OC)c3c(=O)c2OC)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 4/20 1.00
SLC22A2 O15244 1/20 1.00
SLC22A1 O15245 1/20 1.00
ABCG2 Q9UNQ0 8/20 0.81
ABCB1 P08183 5/20 0.81
ABCC1 P33527 3/20 0.81
CYP3A4 P08684 3/20 0.81
KDM4E B2RXH2 2/20 0.81
MEN1 O00255 1/20 0.81
ALDH1A1 P00352 1/20 0.81
MAPK1 P28482 1/20 0.81
KMT2A Q03164 1/20 0.81
TDP1 Q9NUW8 1/20 0.81
MAPT P10636 2/20 0.65
TUBB4A P04350 1/20 0.65
TUBB P07437 1/20 0.65
TUBA3C P0DPH7 1/20 0.65
PKM P14618 1/20 0.65
XDH P47989 1/20 0.65
TUBA1B P68363 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15635199 0.91 ADORA3 (0.83) ADORA3SLC22A2SLC22A1ABCG2ABCB1
SCHEMBL30741221 0.91 ADORA3 (1.00) ADORA3SLC22A2SLC22A1ABCG2ABCB1
SCHEMBL1664287 0.91 ADORA3 (1.00) ADORA3SLC22A2SLC22A1ABCG2ABCB1
SCHEMBL20100901 0.90 ADORA3 (0.81) ADORA3SLC22A2SLC22A1ABCG2ABCB1
Pentamethylquercetin SCHEMBL30168919 0.90 ABCG2 (1.00) ADORA3SLC22A2SLC22A1ABCG2ABCB1
Pentamethylquercetin SCHEMBL2286327 0.90 ABCG2 (1.00) ADORA3SLC22A2SLC22A1ABCG2ABCB1
Pentamethylquercetin SCHEMBL30168918 0.90 ABCG2 (1.00) ADORA3SLC22A2SLC22A1ABCG2ABCB1
Pentamethylquercetin SCHEMBL29725289 0.90 ABCG2 (1.00) ADORA3SLC22A2SLC22A1ABCG2ABCB1
SCHEMBL20464068 0.88 ADORA3 (1.00) ADORA3SLC22A2SLC22A1ABCG2ABCB1
SCHEMBL29864461 0.88 ADORA3 (1.00) ADORA3SLC22A2SLC22A1ABCG2ABCB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260115248-A1 METHOD FOR PRODUCING BLACK GINGER EXTRACT AND METHOD FOR PRODUCING COMPOSITION MARUZEN PHARM CO LTD (JP) 2026-04-30 US claimed
CN-114867486-B Composition containing black ginger extract and composition for oral administration 丸善制药株式会社 2023-05-30 CN claimed
US-20230021051-A1 Composition Containing Black Ginger Extract and Composition for Oral Administration MARUZEN PHARMACEUTICALS CO., LTD. (JP) 2023-01-19 US claimed
US-20220346435-A1 TOBACCO-DERIVED COMPOSITION REYNOLDS TOBACCO CO R (US) 2022-11-03 US claimed
CN-110432537-B Tobacco-derived O-methylated flavonoid compositions R.J.雷诺兹烟草公司 2022-08-19 CN claimed
CN-114867486-A Composition containing Heijiang extract and oral composition 丸善制药株式会社 2022-08-05 CN claimed
WO-2021131264-A1 COMPOSITION CONTAINING BLACK GINGER EXTRACT AND COMPOSITION FOR ORAL ADMINISTRATION 丸善製薬株式会社 2021-07-01 WO claimed
EP-2906055-B1 METHOD OF EXTRACTING TOBACCO-DERIVED O-METHYLATED FLAVONOID AND USE THEREOF REYNOLDS TOBACCO CO R (US) 2020-12-16 EP claimed
CN-106455665-B Black ginger oil extract and preparation method thereof 三得利控股株式会社 2020-06-30 CN claimed
US-20180117000-A1 ENERGY METABOLIC ACTIVATING AGENT FOR MUSCLE CELLS ORYZA OIL & FAT CHEMICAL CO., LTD. (JP) 2018-05-03 US claimed
US-20170071902-A1 NOX INHIBITOR AND NFkB INHIBITOR CONTAINING METHOXYFLAVONE SUNTORY HOLDINGS LIMITED (JP) 2017-03-16 US claimed
US-20170065509-A1 FAT OR OIL EXTRACT OF BLACK GINGER AND METHOD FOR PRODUCING SAME SUNTORY HOLDINGS LIMITED (JP) 2017-03-09 US claimed
EP-2906055-A1 TOBACCO-DERIVED O-METHYLATED FLAVONOID COMPOSITION R. J. Reynolds Tobacco Company (US) 2015-08-19 EP claimed
US-20140348961-A1 SIRTUIN ACTIVATOR Aburada, Masaki (JP) 2014-11-27 US claimed
EP-2799081-A1 SIRTUIN ACTIVATOR Tokiwa Phytochemical Co., Ltd. (JP) 2014-11-05 EP claimed
US-20140096780-A1 TOBACCO-DERIVED COMPOSITION R.J. REYNOLDS TOBACCO COMPANY (US) 2014-04-10 US claimed
US-20260115248-A1 METHOD FOR PRODUCING BLACK GINGER EXTRACT AND METHOD FOR PRODUCING COMPOSITION MARUZEN PHARM CO LTD (JP) 2026-04-30 US disclosed
CN-119837935-A Pericarpium citri reticulatae extract with hair loss prevention and hair growth effects, and preparation method and application thereof 广东邑祥陈皮有限公司 2025-04-18 CN disclosed
US-20020157939-A1 Process for preparation of polyhydric alcohols NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2002-10-31 US disclosed
US-6066642-A FOR SELECTIVELY BLOCKING THE A3 ADENOSINE RECEPTOR OF A MAMMAL THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2000-05-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260115248-A1 METHOD FOR PRODUCING BLACK GINGER EXTRACT AND METHOD FOR PRODUCING COMPOSITION CYP4F8, CYP4F2, CYP4F11 ADORA3 1764/4885SLC22A2 2815/4885SLC22A1 2585/4885
US-20230021051-A1 Composition Containing Black Ginger Extract and Composition for Oral Administration CYP4F8, CYP4F2, CYP4F11 ADORA3 2126/4885SLC22A2 1051/4885SLC22A1 761/4885
US-20170065509-A1 FAT OR OIL EXTRACT OF BLACK GINGER AND METHOD FOR PRODUCING SAME FABP4, PLIN5, FABP6 ADORA3 3949/4885SLC22A2 1571/4885SLC22A1 1677/4885
US-20180117000-A1 ENERGY METABOLIC ACTIVATING AGENT FOR MUSCLE CELLS SLC2A1, SLC2A2, SLC2A4 ADORA3 1129/4885SLC22A2 115/4885SLC22A1 101/4885
US-20170071902-A1 NOX INHIBITOR AND NFkB INHIBITOR CONTAINING METHOXYFLAVONE NOX1, NFKBIA, NOX5 ADORA3 4826/4885SLC22A2 4124/4885SLC22A1 3939/4885
US-20020157939-A1 Process for preparation of polyhydric alcohols ADH1C, ADH1A, ADH5 ADORA3 1693/4885SLC22A2 4547/4885SLC22A1 4614/4885
US-20140348961-A1 SIRTUIN ACTIVATOR SIRT1, HDAC1, SIRT2 ADORA3 1184/4885SLC22A2 2483/4885SLC22A1 2073/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.