Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 2/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.31 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.31 |
| ▸ | ADK | P55263 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1710488 | 0.89 | NOS3 (0.38) | NOS3NOS1FFAR1EGLN1GABRA1 | |
| SCHEMBL6851297 | 0.86 | GABRA1 (0.33) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL14882956 | 0.79 | ALDH1A1 (0.42) | APPGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL4107898 | 0.77 | APP (0.41) | APPGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL17934728 | 0.77 | ADK (0.37) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL20716885 | 0.77 | NOS3 (0.35) | NOS3NOS1FFAR1EGLN1 | |
| SCHEMBL3254459 | 0.76 | CYP2A6 (0.50) | ACACBFFAR1EGLN1GABRA1GABRG2 | |
| SCHEMBL22146946 | 0.76 | NOS3 (0.34) | NOS3NOS1FFAR1EGLN1 | |
| SCHEMBL308282 | 0.75 | TSHR (0.48) | NOS3NOS1MEN1KMT2A | |
| SCHEMBL3345157 | 0.75 | ACACB (0.45) | ACACBFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9012773-B2 | Thiazole-based compound and uses thereof | NEC CORPORATION (JP) | 2015-04-21 | — | — | US | disclosed |