Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | APEX1 | P27695 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | PLA2G4B | P0C869 | 7/20 | 0.59 |
| ▸ | RARB | P10826 | 4/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7646875 | 0.98 | HTT (0.66) | HTTTP53TSHRPOLBAPEX1 | |
| SCHEMBL15582454 | 0.96 | RARB (0.63) | HTTTP53TSHRPOLBAPEX1 | |
| SCHEMBL2203739 | 0.95 | HTT (0.61) | HTTTP53TSHRPOLBAPEX1 | |
| SCHEMBL4081685 | 0.88 | HTT (0.52) | HTTTP53TSHRPOLBAPEX1 | |
| SCHEMBL1798003 | 0.87 | TP53 (0.72) | HTTTP53TSHRPOLBAPEX1 | |
| SCHEMBL22507145 | 0.87 | PKM (0.57) | HTTTP53TSHRPOLBAPEX1 | |
| SCHEMBL7646498 | 0.86 | HTT (0.50) | HTTTP53TSHRPOLBAPEX1 | |
| SCHEMBL7401721 | 0.85 | TP53 (0.69) | HTTTP53TSHRPOLBAPEX1 | |
| SCHEMBL22614938 | 0.85 | PLA2G4B (0.51) | HTTTP53TSHRPOLBAPEX1 | |
| SCHEMBL7138415 | 0.85 | TP53 (0.60) | HTTTP53TSHRPOLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935512-B1 | REACTIVE MESOGENS | MERCK PATENT GMBH (DE) | 2018-12-26 | — | — | EP | disclosed |
| US-20180148648-A1 | REACTIVE MESOGENS | MERCK PATENT GMBH (DE) | 2018-05-31 | — | — | US | disclosed |
| US-20180148648-A1 | REACTIVE MESOGENS | MERCK PATENT GMBH (DE) | 2018-05-31 | — | — | US | disclosed |
| WO-2016184543-A1 | REACTIVE MESOGENS | MERCK PATENT GMBH (DE) | 2016-11-24 | — | — | WO | disclosed |
| US-20150323722-A1 | REACTIVE MESOGENS | MERCK PATENT GMBH (DE) | 2015-11-12 | — | — | US | disclosed |
| US-20150323722-A1 | REACTIVE MESOGENS | MERCK PATENT GMBH (DE) | 2015-11-12 | — | — | US | disclosed |
| US-20150323722-A1 | REACTIVE MESOGENS | MERCK PATENT GMBH (DE) | 2015-11-12 | — | — | US | disclosed |
| EP-2935512-A1 | REACTIVE MESOGENS | Merck Patent GmbH (DE) | 2015-10-28 | — | — | EP | disclosed |
| WO-2014094949-A1 | REACTIVE MESOGENS | MERCK PATENT GMBH (DE) | 2014-06-26 | — | — | WO | disclosed |
| WO-2014094949-A1 | REACTIVE MESOGENS | MERCK PATENT GMBH (DE) | 2014-06-26 | — | — | WO | disclosed |
| US-8470198-B2 | Mesogenic compounds comprising discotic and calamitic groups | MERCK PATENT GMBH (DE) | 2013-06-25 | — | — | US | disclosed |
| US-8470198-B2 | Mesogenic compounds comprising discotic and calamitic groups | MERCK PATENT GMBH (DE) | 2013-06-25 | — | — | US | disclosed |
| US-8470198-B2 | Mesogenic compounds comprising discotic and calamitic groups | MERCK PATENT GMBH (DE) | 2013-06-25 | — | — | US | disclosed |
| EP-2313474-B1 | MESOGENIC COMPOUNDS COMPRISING DISCOTIC AND CALAMITIC GROUPS | MERCK PATENT GMBH (DE) | 2012-09-05 | — | — | EP | disclosed |
| US-20110147659-A1 | MESOGENIC COMPOUNDS COMPRISING DISCOTIC AND CALAMITIC GROUPS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-06-23 | — | — | US | disclosed |
| US-20110147659-A1 | MESOGENIC COMPOUNDS COMPRISING DISCOTIC AND CALAMITIC GROUPS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-06-23 | — | — | US | disclosed |
| EP-2313474-A1 | MESOGENIC COMPOUNDS COMPRISING DISCOTIC AND CALAMITIC GROUPS | Merck Patent GmbH (DE) | 2011-04-27 | — | — | EP | disclosed |
| WO-2010020312-A1 | MESOGENIC COMPOUNDS COMPRISING DISCOTIC AND CALAMITIC GROUPS | MERCK PATENT GMBH (DE) | 2010-02-25 | — | — | WO | disclosed |
| WO-2010020312-A1 | MESOGENIC COMPOUNDS COMPRISING DISCOTIC AND CALAMITIC GROUPS | MERCK PATENT GMBH (DE) | 2010-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148648-A1 | REACTIVE MESOGENS | MAFG, LSG1, MAS1 | HTT 130/4885TP53 1781/4885TSHR 892/4885 |
| US-20150323722-A1 | REACTIVE MESOGENS | BLM, MAFG, MCRS1 | HTT 184/4885TP53 2963/4885TSHR 1586/4885 |
| US-20110147659-A1 | MESOGENIC COMPOUNDS COMPRISING DISCOTIC AND CALAMITIC GROUPS | CALD1, DIAPH1, CALR | HTT 656/4885TP53 4255/4885TSHR 4625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.