Sugi Predict

Sugi Predict / Compounds / SCHEMBL1667463

SCHEMBL1667463

SCHEMBL1667463

CCOC(=O)c1csc(C(=O)CCCCc2ccccc2)n1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PLA2G4A P47712 3/20 0.62
▸ CES1 P23141 5/20 0.52
▸ NPC1 O15118 5/20 0.52
▸ RAB9A P51151 4/20 0.52
▸ SMN1; SMN2 Q16637 1/20 0.52
▸ CA12 O43570 1/20 0.48
▸ CA1 P00915 1/20 0.48
▸ CA2 P00918 1/20 0.48
▸ CA9 Q16790 1/20 0.48
▸ LMNA P02545 1/20 0.47
▸ GAA P10253 1/20 0.47
▸ DAGLA Q9Y4D2 1/20 0.47
▸ MEN1 O00255 1/20 0.46
▸ ALDH1A1 P00352 1/20 0.46
▸ MAPT P10636 1/20 0.46
▸ KMT2A Q03164 1/20 0.46
▸ CYP1A2 P05177 1/20 0.45
▸ CYP2C19 P33261 1/20 0.45
▸ KDM4E B2RXH2 1/20 0.45
▸ HSP90AA1 P07900 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17368809 0.93 PLA2G4A (0.61) PLA2G4ACES1NPC1RAB9ASMN1; SMN2
SCHEMBL22452269 0.85 PLA2G4A (0.54) PLA2G4ACES1NPC1RAB9ASMN1; SMN2
SCHEMBL20662520 0.84 PLA2G4A (0.68) PLA2G4ANPC1RAB9ASMN1; SMN2CA12
SCHEMBL1667949 0.84 PLA2G4A (0.64) PLA2G4ACES1MAPT
SCHEMBL1667122 0.83 PLA2G4A (0.71) PLA2G4ANPC1RAB9ASMN1; SMN2CA12
SCHEMBL1667606 0.82 ALDH1A1 (0.52) PLA2G4ACES1NPC1RAB9ASMN1; SMN2
SCHEMBL12548644 0.82 CES1 (0.56) PLA2G4ACES1DAGLA
SCHEMBL20662525 0.81 PLA2G4A (0.59) PLA2G4ACES1DAGLAMAPT
SCHEMBL1667088 0.78 PLA2G4A (0.48) PLA2G4ANPC1RAB9ASMN1; SMN2CA12
SCHEMBL12548449 0.77 PLA2G4A (0.59) PLA2G4ACES1DAGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11691959-B2 Anti-inflammatory and antitumor 2-oxothiazoles and 2-oxothiophenes compounds AVEXXIN AS (NO) 2023-07-04 — — US disclosed
US-11691959-B2 Anti-inflammatory and antitumor 2-oxothiazoles and 2-oxothiophenes compounds AVEXXIN AS (NO) 2023-07-04 — — US disclosed
US-20220363659-A1 ANTI-INFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES AND 2-OXOTHIOPHENES COMPOUNDS AVEXXIN AS (NO) 2022-11-17 — — US disclosed
US-10370344-B2 2-oxothiazole compounds and method of using same for chronic inflammatory disorders AVEXXIN AS (NO) 2019-08-06 — — US disclosed
US-10370344-B2 2-oxothiazole compounds and method of using same for chronic inflammatory disorders AVEXXIN AS (NO) 2019-08-06 — — US disclosed
US-10259801-B2 Anti-inflammatory and antitumor 2-oxothiazoles ABD 2-oxothiophenes compounds AVEXXIN AS (NO) 2019-04-16 — — US disclosed
EP-3431084-A1 ANTIINFLAMMATORY 2-OXOTHIAZOLES Avexxin AS (NO) 2019-01-23 — — EP disclosed
EP-3431084-A1 ANTIINFLAMMATORY 2-OXOTHIAZOLES Avexxin AS (NO) 2019-01-23 — — EP disclosed
EP-2482815-B1 ANTIINFLAMMATORY 2-OXOTHIAZOLES AND 2-OXOOXAZOLES AVEXXIN AS (NO) 2018-05-02 — — EP disclosed
EP-2482815-B1 ANTIINFLAMMATORY 2-OXOTHIAZOLES AND 2-OXOOXAZOLES AVEXXIN AS (NO) 2018-05-02 — — EP disclosed
CN-104892542-A ANTI INFLAMMATORY 2-OXOTHIAZOLES AND 2 -OXOOXAZOLES AVEXXIN AS 2015-09-09 — — CN disclosed
CN-102647984-B Anti-inflammatory 2-carbonylthiazoles and 2-carbonyloxazoles AVEXXIN AS 2015-03-25 — — CN disclosed
CN-103772312-A ANTI INFLAMMATORY 2-OXOTHIAZOLES AND 2 -OXOOXAZOLES AVEXXIN AS 2014-05-07 — — CN disclosed
CN-102647984-A Anti-inflammatory 2-carbonylthiazoles and 2-carbonyloxazoles AVEXXIN AS 2012-08-22 — — CN disclosed
EP-2482815-A1 ANTI INFLAMMATORY 2-OXOTHIAZOLES AND 2 -OXOOXAZOLES Avexxin AS (NO) 2012-08-08 — — EP disclosed
US-20110136879-A1 COMPOUND AVEXXIN AS (NO) 2011-06-09 — — US disclosed
US-20110136879-A1 COMPOUND AVEXXIN AS (NO) 2011-06-09 — — US disclosed
US-20110136879-A1 COMPOUND AVEXXIN AS (NO) 2011-06-09 — — US disclosed
WO-2011039365-A1 ANTI INFLAMMATORY 2-OXOTHIAZOLES AND 2 -OXOOXAZOLES AVEXXIN AS (NO) 2011-04-07 — — WO disclosed
WO-2011039365-A1 ANTI INFLAMMATORY 2-OXOTHIAZOLES AND 2 -OXOOXAZOLES AVEXXIN AS (NO) 2011-04-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110136879-A1 COMPOUND CBR1, CBR3, CCR1 PLA2G4A 1999/4885CES1 59/4885NPC1 116/4885
US-10259801-B2 Anti-inflammatory and antitumor 2-oxothiazoles ABD 2-oxothiophenes compounds OXER1, CCL2, IL6 PLA2G4A 589/4885CES1 534/4885NPC1 2209/4885
US-20220363659-A1 ANTI-INFLAMMATORY AND ANTITUMOR 2-OXOTHIAZOLES AND 2-OXOTHIOPHENES COMPOUNDS OXER1, CASP1, IL6 PLA2G4A 1539/4885CES1 527/4885NPC1 1280/4885
US-11691959-B2 Anti-inflammatory and antitumor 2-oxothiazoles and 2-oxothiophenes compounds CASP1, IL1B, OXER1 PLA2G4A 1579/4885CES1 379/4885NPC1 839/4885
US-10370344-B2 2-oxothiazole compounds and method of using same for chronic inflammatory disorders CX3CR1, LTC4S, CBR1 PLA2G4A 1174/4885CES1 155/4885NPC1 274/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.