Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | DBH | P09172 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.38 |
| ▸ | CHRNG | P07510 | 1/20 | 0.38 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | CHRND | Q07001 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24337482 | 0.87 | POLB (0.42) | KDM4EDBHGAARECQLFFAR1 | |
| SCHEMBL13050414 | 0.86 | SLC6A3 (0.46) | KDM4EDBHGAARECQLFFAR1 | |
| SCHEMBL26473847 | 0.86 | GPR139 (0.44) | KDM4EDBHGAARECQLFFAR1 | |
| SCHEMBL26873642 | 0.82 | NOTUM (0.54) | KDM4EDBHGAARECQLALDH1A1 | |
| SCHEMBL9962964 | 0.82 | GAA (0.56) | KDM4EDBHGAARECQLFFAR1 | |
| SCHEMBL19958378 | 0.81 | NOTUM (0.61) | KDM4EDBHGAARECQLGSK3B | |
| SCHEMBL20646887 | 0.81 | GAA (0.37) | KDM4EDBHGAARECQLFFAR1 | |
| SCHEMBL29475436 | 0.81 | GSK3B (0.42) | KDM4EDBHGAARECQLGABRA1 | |
| SCHEMBL24337483 | 0.81 | GSK3B (0.42) | KDM4EDBHGAARECQLGABRA1 | |
| SCHEMBL3125040 | 0.79 | CHRNA1 (0.59) | KDM4EDBHGAARECQLSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11759453-B2 | SHMT inhibitors | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2023-09-19 | — | — | US | disclosed |
| US-11759453-B2 | SHMT inhibitors | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2023-09-19 | — | — | US | disclosed |
| US-20180117010-A1 | SHMT Inhibitors | THE TRUSTEES OF PRINCETON UNIVERSITY | 2018-05-03 | — | — | US | disclosed |
| US-9480259-B2 | Pyrazolopyrans having herbicidal and pharmaceutical properties | BASF SE (DE) | 2016-11-01 | — | — | US | disclosed |
| US-9480259-B2 | Pyrazolopyrans having herbicidal and pharmaceutical properties | BASF SE (DE) | 2016-11-01 | — | — | US | disclosed |
| US-9480259-B2 | Pyrazolopyrans having herbicidal and pharmaceutical properties | BASF SE (DE) | 2016-11-01 | — | — | US | disclosed |
| WO-2016145252-A1 | SHMT INHIBITORS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016145252-A1 | SHMT INHIBITORS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2016-09-15 | — | — | WO | disclosed |
| US-20150126371-A1 | PYRAZOLOPYRANS HAVING HERBICIDAL AND PHARMACEUTICAL PROPERTIES | BASF SE (DE) | 2015-05-07 | — | — | US | disclosed |
| US-20150126371-A1 | PYRAZOLOPYRANS HAVING HERBICIDAL AND PHARMACEUTICAL PROPERTIES | BASF SE (DE) | 2015-05-07 | — | — | US | disclosed |
| US-20150126371-A1 | PYRAZOLOPYRANS HAVING HERBICIDAL AND PHARMACEUTICAL PROPERTIES | BASF SE (DE) | 2015-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11759453-B2 | SHMT inhibitors | SHMT1, SHMT2, BHMT | KDM4E 229/4885DBH 387/4885GAA 2727/4885 |
| US-20150126371-A1 | PYRAZOLOPYRANS HAVING HERBICIDAL AND PHARMACEUTICAL PROPERTIES | SHMT1, TPST2, SHMT2 | KDM4E 2260/4885DBH 1910/4885GAA 685/4885 |
| US-20180117010-A1 | SHMT Inhibitors | SHMT1, SHMT2, BHMT | KDM4E 978/4885DBH 3712/4885GAA 3628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.