Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 13/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.54 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.54 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.52 |
| ▸ | PTGES | O14684 | 2/20 | 0.52 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16700722 | 1.00 | TAS2R14 (0.56) | TAS2R14KMT2AMEN1NR3C1MEP1B | |
| SCHEMBL16700016 | 0.98 | TAS2R14 (0.58) | TAS2R14KMT2AMEN1NR3C1MEP1B | |
| Hydrochloric Acid SCHEMBL16699939 | 0.90 | MEP1B (0.59) | TAS2R14KMT2AMEN1MEP1BCXCR3 | |
| SCHEMBL4743378 | 0.88 | MEP1B (0.61) | TAS2R14KMT2AMEN1MEP1BCXCR3 | |
| SCHEMBL11809995 | 0.88 | MEP1B (0.61) | TAS2R14KMT2AMEN1MEP1BCXCR3 | |
| SCHEMBL16700730 | 0.84 | NR3C1 (0.58) | NR3C1PTPN1 | |
| SCHEMBL16706846 | 0.83 | LMNA (0.62) | TAS2R14KMT2AMEN1MEP1BCXCR3 | |
| SCHEMBL21940191 | 0.83 | SRD5A2 (0.61) | TAS2R14KMT2AMEN1MEP1BCXCR3 | |
| SCHEMBL20902751 | 0.83 | MAPT (0.57) | TAS2R14NR3C1MEP1BCXCR3PTGES | |
| Benzoic Acid SCHEMBL31121247 | 0.82 | DAO (0.61) | TAS2R14KMT2AMEN1MEP1BPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2861568-B1 | TERTIARY AMINES FOR USE IN THE TREATMENT OF CARDIAC DISORDERS | UNIV OSLO (NO) | 2019-04-17 | — | — | EP | disclosed |
| US-9951033-B2 | Tertiary amines for use in the treatment of cardiac disorders | UNIVERSITETET I OSLO (NO) | 2018-04-24 | — | — | US | disclosed |
| US-20170158657-A1 | TERTIARY AMINES FOR USE IN THE TREATMENT OF CARDIAC DISORDERS | UNIVERSITETET I OSLO (NO) | 2017-06-08 | — | — | US | disclosed |
| US-9556111-B2 | Tertiary amines for use in the treatment of cardiac disorders | UNIVERSITETET I OSLO (NO) | 2017-01-31 | — | — | US | disclosed |
| US-20150133510-A1 | TERTIARY AMINES FOR USE IN THE TREATMENT OF CARDIAC DISORDERS | UNIVERSITETET I OSLO (NO) | 2015-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170158657-A1 | TERTIARY AMINES FOR USE IN THE TREATMENT OF CARDIAC DISORDERS | TNNI3, TNNT2, MYLK2 | TAS2R14 3501/4885KMT2A 976/4885MEN1 3450/4885 |
| US-20150133510-A1 | TERTIARY AMINES FOR USE IN THE TREATMENT OF CARDIAC DISORDERS | TNNI3, TNNT2, MYLK2 | TAS2R14 3766/4885KMT2A 904/4885MEN1 3518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.