Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.41 |
| ▸ | MAOB | P27338 | 4/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | HTR1A | P08908 | 7/20 | 0.41 |
| ▸ | DRD2 | P14416 | 7/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16703990 | 0.87 | MAOA (0.39) | MAOAMAOBHRH3HTR1ADRD2 | |
| SCHEMBL16702411 | 0.87 | KCNH2 (0.45) | MAOAMAOBHRH3GAA | |
| SCHEMBL16701948 | 0.87 | HRH3 (0.40) | MAOAMAOBHRH3HTR1ADRD2 | |
| SCHEMBL16702375 | 0.86 | HTR1A (0.39) | HTR1ADRD2UTS2R | |
| SCHEMBL16701987 | 0.85 | DRD2 (0.59) | HTR1ADRD2 | |
| SCHEMBL16701815 | 0.83 | GPR119 (0.43) | HTR1ADRD2 | |
| SCHEMBL16702746 | 0.81 | MBTD1 (0.43) | HRH3HTR1ADRD2GAA | |
| SCHEMBL16701992 | 0.79 | HRH3 (0.53) | HRH3HTR1ADRD2 | |
| SCHEMBL2450534 | 0.77 | HTR2C (0.47) | HTR1A | |
| SCHEMBL16704219 | 0.76 | MAOB (0.43) | MAOAMAOBHRH3HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015069110-A1 | MULTIPLE D2 A(NTA)GONISTS/H3 ANTAGONISTS FOR TREATMENT OF CNS-RELATED DISORDERS | AAPA B.V. (NL) | 2015-05-14 | — | — | WO | disclosed |
| WO-2015069110-A1 | MULTIPLE D2 A(NTA)GONISTS/H3 ANTAGONISTS FOR TREATMENT OF CNS-RELATED DISORDERS | AAPA B.V. (NL) | 2015-05-14 | — | — | WO | disclosed |