Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP14 | P50281 | 2/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4196181 | 0.78 | ALDH1A1 (0.41) | MAPTELANEKMT2A | |
| SCHEMBL16702992 | 0.75 | CA2 (0.50) | PTGS2CYP11B1CYP11B2POLBMAPT | |
| SCHEMBL16703079 | 0.74 | PTGS2 (0.48) | PTGS2CYP11B1CYP11B2POLBMAPT | |
| SCHEMBL2294329 | 0.73 | PTGS2 (0.44) | PTGS2CYP11B1CYP11B2POLBMAPT | |
| SCHEMBL2294327 | 0.73 | PTGS2 (0.44) | PTGS2CYP11B1CYP11B2POLBMAPT | |
| SCHEMBL3234259 | 0.73 | MMP2 (0.42) | PTGS2CYP11B1CYP11B2POLBMAPT | |
| SCHEMBL9352386 | 0.72 | ELANE (0.62) | PTGS2CYP11B1CYP11B2POLBMAPT | |
| SCHEMBL1930857 | 0.72 | MAPT (0.74) | PTGS2POLBMAPTPKMENPP2 | |
| SCHEMBL14596348 | 0.71 | THRB (0.53) | PTGS2CYP11B1CYP11B2POLBMAPT | |
| SCHEMBL27825837 | 0.71 | PTGS2 (0.50) | PTGS2CYP11B1CYP11B2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3066091-A1 | NMDA ANTAGONIST PRODRUGS | Astrazeneca AB (SE) | 2016-09-14 | — | — | EP | disclosed |
| WO-2015067923-A1 | NMDA ANTAGONIST PRODRUGS | ASTRAZENECA AB (SE) | 2015-05-14 | — | — | WO | disclosed |