Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1670381 | 0.82 | MAPKAPK2 (0.41) | MAPKAPK2ADORA1MEN1KMT2AMAPT | |
| SCHEMBL16412158 | 0.80 | PREP (0.40) | MAPKAPK2 | |
| SCHEMBL12800389 | 0.79 | MAPT (0.44) | MAPKAPK2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL28350054 | 0.76 | GRM2 (0.47) | MAPKAPK2ADORA1MEN1KMT2AMAPT | |
| SCHEMBL1670709 | 0.72 | PTGS2 (0.48) | NPSR1 | |
| SCHEMBL12800377 | 0.70 | MAPT (0.44) | MAPKAPK2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL1185054 | 0.70 | ALDH1A1 (0.47) | MAPKAPK2ADORA1PTPN1MEN1KMT2A | |
| SCHEMBL7689092 | 0.69 | POLB (0.49) | MAPKAPK2ADORA1PTPN1MEN1KMT2A | |
| SCHEMBL1670782 | 0.68 | ADORA1 (0.44) | MAPKAPK2ADORA1PTPN1MEN1KMT2A | |
| SCHEMBL140629 | 0.68 | PGR (0.49) | MAPKAPK2ADORA1PTPN1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042477-A1 | SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |