SCHEMBL167137

SCHEMBL167137

COc1cc(O)ccc1Br

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.61
ALOX5 P09917 1/20 0.57
PTGS2 P35354 1/20 0.57
ESR1 P03372 3/20 0.52
ESR2 Q92731 2/20 0.52
MAPT P10636 2/20 0.48
CYP3A4 P08684 1/20 0.48
ERN1 O75460 1/20 0.44
APP P05067 1/20 0.43
MGAM O43451 1/20 0.43
GAA P10253 1/20 0.43
SI P14410 1/20 0.43
MGAM2 Q2M2H8 1/20 0.43
ALDH1A1 P00352 2/20 0.42
PTPN1 P18031 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
CAPN1 P07384 1/20 0.41
PARP1 P09874 1/20 0.41
MAOA P21397 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29692497 0.82 ALOX5 (0.57) MAOBALOX5PTGS2ESR1ESR2
SCHEMBL517614 0.82 ALOX5 (0.57) MAOBALOX5PTGS2ESR1ESR2
SCHEMBL9623648 0.81 MAOB (0.67) MAOBALOX5PTGS2ESR1ESR2
SCHEMBL119396 0.78 MAOB (0.70) MAOBPTGS2ESR1ESR2MAPT
SCHEMBL30514387 0.78 MAOB (0.70) MAOBPTGS2ESR1ESR2MAPT
SCHEMBL9122395 0.78 BACE1 (0.46) MAOBALOX5PTGS2ESR1ESR2
SCHEMBL9939154 0.78 ESR1 (0.57) MAOBALOX5PTGS2ESR1ESR2
SCHEMBL4677324 0.77 MAOB (0.41) MAOBALOX5PTGS2ESR1ESR2
SCHEMBL1697735 0.77 TSHR (0.44) MAOBMAPTGAAALDH1A1MEN1
SCHEMBL15384783 0.77 SLC6A4 (0.49) MAOBALOX5PTGS2MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 690 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120058566-A Synthesis method and application of trifluoro-methanesulfonyl ester substituted macrocyclic aromatic hydrocarbon 天津师范大学 2025-05-30 CN claimed
CN-119119040-A Preparation method of non-neridrone intermediate 广西天铭药业有限公司 2024-12-13 CN claimed
CN-118930433-A Preparation method and application of serial functional conjugated nano-rings containing ring para-phenylene skeleton 天津师范大学 2024-11-12 CN claimed
CN-118638106-A Novel method for synthesizing hexamethylation sophoraflavanone J 西南交通大学 2024-09-13 CN claimed
CN-110317129-A The synthetic method of the bromo- 5- metoxyphenol of 2- 杭州迈世腾药物科技有限公司 2019-10-11 CN claimed
CN-105348799-A Nitrogen compound flame retardant and preparation method thereof NINGXIA RUNLONG PACKAGING MATERIAL CO LTD 2016-02-24 CN claimed
CN-101910308-B Curing composition and cured product prepared by using the same LG CHEMICAL LTD 2012-11-21 CN claimed
CN-101910308-A Curing composition and cured product prepared by using the same LG CHEMICAL LTD 2010-12-08 CN claimed
EP-0351336-B1 PROCESS FOR THE PREPARATION OF HYDROXYBENZALDEHYDES BY HYDROCARBONYLATION RHONE-POULENC CHIMIE (FR) 1992-10-28 EP claimed
US-12595243-B2 Modulators of extracellular signal-regulated kinase GEN1E LIFESCIENCES INC. (US) 2026-04-07 US disclosed
EP-3526196-B1 ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS MERCK SHARP & DOHME LLC (US) 2026-03-18 EP disclosed
US-12570607-B2 Compound as cyclin-dependent kinase 9 inhibitor and use thereof CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD. (CN) 2026-03-10 US disclosed
US-12509460-B2 Methods and compositions for modulating splicing SKYHAWK THERAPEUTICS, INC. (US) 2025-12-30 US disclosed
US-12492344-B2 Liquid-crystal medium comprising polymerizable compounds MERCK PATENT GMBH (DE) 2025-12-09 US disclosed
US-3980659-A INSECTICIDES, INTERMEDIATES FOR AZO DYES CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) 1976-09-14 US disclosed
US-3959388-A Preparation of phloroglucinol or its monomethyl ether ANDENO B.V. (NL) 1976-05-25 US disclosed
US-3956294-A AZO DYES, PESTICIDES, ANALEPTICS, ANALGESICS, DIURETICS CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) 1976-05-11 US disclosed
US-3954782-A 2,6-Hydrazino-3-pyridine carboxyamides CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) 1976-05-04 US disclosed
US-3947463-A Certain 2-amino-nicotinonitrile derivatives CASSELLA FARBWERKE MAINKUR AG (DT) 1976-03-30 US disclosed
US-3946024-A INTERMEDIATES FOR AZO DYES CASSELLA FARBWERKE MAINKUR AG (DT) 1976-03-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12509460-B2 Methods and compositions for modulating splicing SF3B1, RTCB, RBM17 MAOB 3315/4885ALOX5 1855/4885PTGS2 2820/4885
US-12570607-B2 Compound as cyclin-dependent kinase 9 inhibitor and use thereof CDK9, CDK4, CDKL4 MAOB 4091/4885ALOX5 4775/4885PTGS2 3250/4885
US-12492344-B2 Liquid-crystal medium comprising polymerizable compounds NEFM, LPXN, SPAST MAOB 1827/4885ALOX5 1342/4885PTGS2 4473/4885
US-12595243-B2 Modulators of extracellular signal-regulated kinase CDC42BPG, GRK3, ERBB2 MAOB 3970/4885ALOX5 3342/4885PTGS2 1220/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.