Sugi Predict

Sugi Predict / Compounds / SCHEMBL517614

SCHEMBL517614

SCHEMBL517614

COc1ccc(O)cc1Br

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALOX5 P09917 1/20 0.57
▸ PTGS2 P35354 1/20 0.57
▸ ALDH1A1 P00352 3/20 0.57
▸ MAOB P27338 1/20 0.56
▸ CTSL P07711 3/20 0.51
▸ CYP1A2 P05177 1/20 0.49
▸ CYP2D6 P10635 1/20 0.49
▸ HPGD P15428 1/20 0.49
▸ CYP2C19 P33261 1/20 0.49
▸ MEN1 O00255 2/20 0.47
▸ KMT2A Q03164 2/20 0.47
▸ LMNA P02545 1/20 0.47
▸ MAPT P10636 4/20 0.46
▸ MAPK1 P28482 1/20 0.46
▸ TUBB1 Q9H4B7 2/20 0.46
▸ OPRK1 P41145 1/20 0.44
▸ ABCG2 Q9UNQ0 1/20 0.44
▸ ERN1 O75460 1/20 0.44
▸ HSD17B10 Q99714 2/20 0.44
▸ KDM4E B2RXH2 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29692497 1.00 ALOX5 (0.57) ALOX5PTGS2ALDH1A1MAOBCTSL
SCHEMBL6641490 0.84 ESR2 (0.50) ALOX5PTGS2ALDH1A1MAOBCTSL
SCHEMBL167137 0.82 MAOB (0.61) ALOX5PTGS2ALDH1A1MAOBCTSL
SCHEMBL9623652 0.81 MAPK1 (0.58) ALOX5PTGS2ALDH1A1MAOBHPGD
SCHEMBL20429128 0.79 PTGS1 (0.51) ALOX5PTGS2ALDH1A1CTSLCYP1A2
SCHEMBL12804866 0.79 MEN1 (0.39) ALOX5PTGS2ALDH1A1MAOBCTSL
SCHEMBL28854441 0.79 LMNA (0.39) ALOX5PTGS2ALDH1A1MAOBCTSL
SCHEMBL30514387 0.78 MAOB (0.70) PTGS2ALDH1A1MAOBCYP1A2HPGD
SCHEMBL119396 0.78 MAOB (0.70) PTGS2ALDH1A1MAOBCYP1A2HPGD
SCHEMBL9939154 0.78 ESR1 (0.57) ALOX5PTGS2ALDH1A1MAOBCTSL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 166 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119841715-A Method for directly preparing aromatic ether compound from aromatic aldehyde, ketone and phenol 湖南第一师范学院 2025-04-18 — — CN claimed
CN-116478199-A Bimetallic catalyst and preparation method thereof, and preparation method of high molecular weight olefin polymer 万华化学集团股份有限公司 2023-07-25 — — CN claimed
CN-112374984-A Preparation process of 2-bromo-4-hydroxyanisole 苏州求索生物科技有限公司 2021-02-19 — — CN claimed
CN-105001107-B A kind of method of synthesizing methyl Hongmaoxinjian 西安交通大学 2016-08-17 — — CN claimed
CN-105001107-A Synthetic method for methyl caulophine UNIV XI AN JIAOTONG 2015-10-28 — — CN claimed
CN-102753538-B Sultam derivatives HOFFMANN LA ROCHE 2015-04-08 — — CN claimed
CN-102753538-A Sultam derivatives HOFFMANN LA ROCHE 2012-10-24 — — CN claimed
EP-4747247-A1 NOVEL FATTY ACID AMIDE HYDROLASE MODULATORS, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF Apogee Pharmaceuticals, Inc. (CA) 2026-05-27 — — EP disclosed
CN-122059950-A Compounds with proteasome agonistic activity, preparation method and application thereof 浙大城市学院 2026-05-19 — — CN disclosed
EP-4665339-A1 INHIBITING ALPHA V BETA 8 INTEGRIN Morphic Therapeutic, Inc. (US) 2025-12-24 — — EP disclosed
US-12435060-B2 Acylamino bridged heterocyclic compound, and composition and application thereof BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED (CN) 2025-10-07 — — US disclosed
US-12410137-B2 Fatty acid amide hydrolase modulators, compositions comprising the same and uses thereof APOGEE PHARMACEUTICALS, INC. (CA) 2025-09-09 — — US disclosed
WO-2025133660-A1 NOVEL COMPOUNDS FOR HOST DIRECTED ANTIVIRAL STRATEGY SORBONNE UNIVERSITE (FR) 2025-06-26 — — WO disclosed
US-20030087935-A1 Substituted acid derivatives useful as antidiabetic and antiobesity agents and method CHENG PETER T (US) 2003-05-08 — — US disclosed
US-20030069275-A1 Substituted acid derivatives useful as antidiabetic and antiobesity agents and method CHENG PETER T (US) 2003-04-10 — — US disclosed
CN-1374955-A Oxazole and thiazole derivatives as antidiabetic and antiobesity agents BRISTOL MYERS SQUIBB CO (US) 2002-10-16 — — CN disclosed
EP-1218361-A1 OXA- AND THIAZOLE DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 2002-07-03 — — EP disclosed
US-6414002-B1 ANTILIPEMIC AGENTS; ANTICANCER, ANTITUMOR AGENTS BRISTOL-MYERS SQUIBB COMPANY 2002-07-02 — — US disclosed
WO-2001021602-A1 OXA- AND THIAZOLE DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 2001-03-29 — — WO disclosed
CN-1154697-A Oxygen-contg. heterocyclic compound KYOWA HAKKO KOGYO KK (JP) 1997-07-16 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030069275-A1 Substituted acid derivatives useful as antidiabetic and antiobesity agents and method GPR119, LIPC, PNLIP ALOX5 1237/4885PTGS2 3492/4885ALDH1A1 1167/4885
US-20030087935-A1 Substituted acid derivatives useful as antidiabetic and antiobesity agents and method GPR119, LIPC, PNLIP ALOX5 1237/4885PTGS2 3492/4885ALDH1A1 1167/4885
US-12410137-B2 Fatty acid amide hydrolase modulators, compositions comprising the same and uses thereof FAAH, FAAH2, MGLL ALOX5 20/4885PTGS2 249/4885ALDH1A1 470/4885
US-12435060-B2 Acylamino bridged heterocyclic compound, and composition and application thereof RIPK1, RIPK3, RIPK4 ALOX5 2444/4885PTGS2 3872/4885ALDH1A1 4164/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback