Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.61 |
| ▸ | HTR6 | P50406 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.57 |
| ▸ | NQO2 | P16083 | 3/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 11/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 11/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16711692 | 0.99 | HTR1D (0.60) | HTR1DHTR6KDM4EALDH1A1HPGD | |
| SCHEMBL2403262 | 0.86 | HTR1D (0.65) | HTR1DHTR6KDM4EALDH1A1HPGD | |
| SCHEMBL15427782 | 0.85 | KDM4E (0.79) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL16711851 | 0.85 | ALDH1A1 (0.65) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL16711699 | 0.85 | KDM4E (0.69) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL16711952 | 0.84 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL16923032 | 0.84 | EGFR (0.52) | HTR1DHTR6KDM4EALDH1A1HPGD | |
| SCHEMBL15427985 | 0.84 | HTR6 (0.60) | HTR1DHTR6KDM4EALDH1A1HPGD | |
| SCHEMBL18235616 | 0.83 | TRPM8 (0.66) | HTR6KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL15427778 | 0.83 | ALDH1A1 (0.63) | KDM4EALDH1A1HPGDHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2873660-B1 | INDOLECARBOXAMIDE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2016-10-26 | — | — | EP | disclosed |
| US-9376449-B2 | Indole carboxamide derivative | ASTELLAS PHARMA INC. (JP) | 2016-06-28 | — | — | US | disclosed |
| US-20150203505-A1 | INDOLE CARBOXAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2015-07-23 | — | — | US | disclosed |
| EP-2873660-A1 | INDOLECARBOXAMIDE DERIVATIVE | Astellas Pharma Inc. (JP) | 2015-05-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150203505-A1 | INDOLE CARBOXAMIDE DERIVATIVE | MTNR1A, MTNR1B, IDO2 | HTR1D 63/4885HTR6 85/4885KDM4E 1577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.