Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Clonazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 7/20 | 0.61 |
| ▸ | GABRA5 known ✓ | P31644 | 7/20 | 0.61 |
| ▸ | GABRA3 known ✓ | P34903 | 7/20 | 0.61 |
| ▸ | GABRG2 known ✓ | P18507 | 6/20 | 0.61 |
| ▸ | GABRB3 known ✓ | P28472 | 6/20 | 0.61 |
| ▸ | GABRA2 known ✓ | P47869 | 6/20 | 0.61 |
| ▸ | GABRB2 known ✓ | P47870 | 6/20 | 0.61 |
| ▸ | GABRP known ✓ | O00591 | 4/20 | 0.61 |
| ▸ | GABRD known ✓ | O14764 | 4/20 | 0.61 |
| ▸ | GABRB1 known ✓ | P18505 | 4/20 | 0.61 |
| ▸ | GABRA4 known ✓ | P48169 | 4/20 | 0.61 |
| ▸ | GABRE known ✓ | P78334 | 4/20 | 0.61 |
| ▸ | GABRA6 known ✓ | Q16445 | 4/20 | 0.61 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 4/20 | 0.61 |
| ▸ | GABRG3 known ✓ | Q99928 | 4/20 | 0.61 |
| ▸ | GABRQ known ✓ | Q9UN88 | 4/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 6/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clonazepam SCHEMBL17728660 | 0.88 | GABRA1 (0.67) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| Clonazepam SCHEMBL5500649 | 0.85 | GABRA1 (0.74) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| Flunitrazepam SCHEMBL8364961 | 0.84 | GABRA1 (0.64) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| Nitrazepam SCHEMBL1956552 | 0.84 | LMNA (0.70) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| Meclonazepam SCHEMBL1003386 | 0.83 | OPRK1 (0.63) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| Flunitrazepam SCHEMBL18316507 | 0.82 | GABRA1 (0.63) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| Flurazepam SCHEMBL10351229 | 0.81 | OPRK1 (0.57) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| Delorazepam SCHEMBL6130036 | 0.81 | LMNA (0.73) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| Alprazolam SCHEMBL3905590 | 0.81 | GABRA1 (0.62) | GABRA1GABRA5GABRA3GABRG2GABRB3 | |
| Clonazepam SCHEMBL20771795 | 0.80 | GABRA1 (0.96) | GABRA1GABRA5GABRA3GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015070873-A1 | DETECTION OF SUBSTANCES IN LIQUIDS, IN PARTICULAR PSYCHOACTIVE SUBSTANCES | DRUGSTER APS (DK) | 2015-05-21 | — | — | WO | disclosed |