Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | HSD17B14 | Q9BPX1 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CA3 | P07451 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16720271 | 0.85 | MAPT (0.39) | KDM4ENPC1CA12GMNNALDH1A1 | |
| SCHEMBL12815748 | 0.83 | CCNE2 (0.35) | CES2BCHECES1PIK3CASLC9A1 | |
| SCHEMBL16720251 | 0.79 | CA2 (0.35) | CES2CES1KDM4ENPC1CA12 | |
| SCHEMBL2053579 | 0.79 | ACHE (0.39) | NPC1RAB9ASMN1; SMN2BCAT1CCNE2 | |
| SCHEMBL2014554 | 0.79 | TAAR1 (0.34) | KDM4ETDP1BCAT1CCNE2CCNE1 | |
| SCHEMBL2373478 | 0.77 | SMN1; SMN2 (0.46) | KDM4ENPC1CA12GMNNALDH1A1 | |
| SCHEMBL2049471 | 0.76 | HSD11B1 (0.46) | CES1 | |
| SCHEMBL16720359 | 0.74 | ALDH1A1 (0.40) | CES2CES1KDM4EALDH1A1CA2 | |
| SCHEMBL6367917 | 0.72 | ALDH1A1 (0.44) | CES2BCHECES1HSD17B14KDM4E | |
| SCHEMBL27341090 | 0.72 | MAOA (0.46) | CES2BCHECES1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |