Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 20/20 | 0.64 |
| ▸ | PDK2 | Q15119 | 20/20 | 0.64 |
| ▸ | PDK3 | Q15120 | 20/20 | 0.64 |
| ▸ | PDK4 | Q16654 | 20/20 | 0.64 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16735680 | 0.81 | POLB (0.42) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL2144029 | 0.80 | PDK1 (0.58) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL16735643 | 0.79 | LMNA (0.53) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL16590055 | 0.78 | PDK1 (1.00) | PDK1PDK2PDK3PDK4HSP90AA1 | |
| SCHEMBL16735666 | 0.78 | LMNA (0.53) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL16735559 | 0.77 | HSP90AA1 (0.40) | PDK1PDK2PDK3PDK4HSP90AA1 | |
| SCHEMBL16735553 | 0.75 | GPBAR1 (0.43) | PDK1PDK2PDK3PDK4HSP90AA1 | |
| SCHEMBL16735636 | 0.75 | HSP90AA1 (0.62) | HSP90AA1 | |
| SCHEMBL16735620 | 0.75 | KCNH2 (0.45) | HSP90AA1 | |
| SCHEMBL16735667 | 0.74 | POLB (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |