Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 11/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 11/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 11/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 11/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16735620 | 0.83 | KCNH2 (0.45) | POLBHPGDTP53RAB9ARXFP1 | |
| SCHEMBL16735667 | 0.82 | POLB (0.51) | POLBHPGDTP53RAB9ARXFP1 | |
| SCHEMBL16735659 | 0.81 | PDK1 (0.64) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL16735670 | 0.79 | MAPT (0.55) | POLBHPGDHTTTP53RECQL | |
| SCHEMBL16735647 | 0.78 | POLB (0.49) | POLBRAB9ARXFP1ALDH1A1 | |
| SCHEMBL16735639 | 0.78 | RXFP1 (0.46) | POLBMCL1RXFP1 | |
| SCHEMBL16735578 | 0.77 | POLB (0.56) | POLBHPGDTP53RXFP1ALDH1A1 | |
| SCHEMBL16735553 | 0.76 | GPBAR1 (0.43) | POLBPDK1PDK2PDK3PDK4 | |
| SCHEMBL16735593 | 0.76 | RXFP1 (0.56) | POLBHPGDRXFP1 | |
| SCHEMBL16735643 | 0.76 | LMNA (0.53) | POLBPDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |