Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 7/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16735647 | 0.88 | POLB (0.49) | POLBCTSBMAPTRAB9AALDH1A1 | |
| SCHEMBL16735670 | 0.86 | MAPT (0.55) | POLBHPGDMAPTNPC1RAB9A | |
| SCHEMBL16735578 | 0.86 | POLB (0.56) | POLBHPGDMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL16735593 | 0.86 | RXFP1 (0.56) | POLBHPGDRXFP1 | |
| SCHEMBL16735605 | 0.85 | POLB (0.51) | POLBALDH1A1RXFP1 | |
| SCHEMBL16735663 | 0.83 | RXFP1 (0.45) | POLBRXFP1 | |
| SCHEMBL16735680 | 0.82 | POLB (0.42) | POLBHPGDRAB9AALDH1A1KMT2A | |
| SCHEMBL16735658 | 0.82 | POLB (0.53) | POLBTSHRMAPTNPC1RAB9A | |
| SCHEMBL16735619 | 0.81 | POLB (0.52) | POLBHPGDRAB9ARXFP1TP53 | |
| SCHEMBL16735620 | 0.81 | KCNH2 (0.45) | POLBHPGDTSHRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |