Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 2/20 | 0.35 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.33 |
| ▸ | KARS1 | Q15046 | 3/20 | 0.33 |
| ▸ | GNRHR | P30968 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 2/20 | 0.31 |
| ▸ | CLK3 | P49761 | 2/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16776023 | 0.84 | GSK3B (0.36) | NPC1RAB9AWNT1KARS1DYRK1A | |
| SCHEMBL16776240 | 0.83 | WNT1 (0.35) | NPC1RAB9AWNT1KARS1GAA | |
| SCHEMBL16775904 | 0.81 | GRM5 (0.42) | RAB9AKMT2AKARS1FAAH | |
| SCHEMBL16775991 | 0.80 | THRB (0.39) | KARS1 | |
| SCHEMBL16776055 | 0.79 | KARS1 (0.49) | KARS1DYRK1AGSK3BFAAH | |
| SCHEMBL19699119 | 0.79 | NPC1 (0.36) | NPC1RAB9AKMT2AWNT1GNRHR | |
| SCHEMBL16776050 | 0.79 | PRMT5 (0.38) | RPS6KA2DYRK1AGSK3BFAAH | |
| SCHEMBL16776168 | 0.77 | DYRK1A (0.38) | KMT2AWNT1KARS1DYRK1AGSK3B | |
| SCHEMBL16776046 | 0.77 | FAAH (0.35) | RPS6KA2GNRHRDYRK1AGSK3BFAAH | |
| SCHEMBL16776107 | 0.76 | RAB9A (0.37) | NPC1RAB9AKMT2AGAADYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | NPC1 3380/4885RAB9A 1471/4885KMT2A 1438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.