Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 2/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8157598 | 1.00 | GRM1 (0.41) | GRM1MEN1KMT2ATDP1CYP1A2 | |
| SCHEMBL27817027 | 0.87 | MEN1 (0.40) | GRM1MEN1KMT2ATDP1CYP1A2 | |
| SCHEMBL3180180 | 0.85 | TDP1 (0.40) | MEN1KMT2ATDP1PTGS1PTGS2 | |
| SCHEMBL1478090 | 0.82 | MT-CO2 (0.42) | MEN1KMT2ATDP1PTGS1PTGS2 | |
| SCHEMBL8960497 | 0.81 | TRPA1 (0.44) | GRM1MEN1KMT2ATDP1CYP1A2 | |
| SCHEMBL8960143 | 0.81 | TRPA1 (0.44) | GRM1MEN1KMT2ATDP1CYP1A2 | |
| SCHEMBL1679175 | 0.80 | PTGS1 (0.51) | MEN1KMT2APTGS1PTGS2FPR2 | |
| SCHEMBL1678601 | 0.80 | PTGS1 (0.38) | PTGS1PTGS2LMNAFPR2PPARA | |
| SCHEMBL20943279 | 0.80 | MAPK1 (0.46) | MEN1KMT2ATDP1PTGS1PTGS2 | |
| SCHEMBL8163812 | 0.80 | MAPK1 (0.46) | MEN1KMT2ATDP1PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3476829-B1 | BIARYL UREA DERIVATIVE OR SALT THEREOF, AND MANUFACTURING AND APPLICATION OF SAME | UNIV FUDAN (CN) | 2021-12-15 | — | — | EP | disclosed |
| US-10851050-B2 | Biaryl urea derivative or salt thereof and preparation process and use for the same | FUDAN UNIVERSITY (CN) | 2020-12-01 | — | — | US | disclosed |
| US-20200239411-A1 | BIARYL UREA DERIVATIVE OR SALT THEREOF AND PREPARATION PROCESS AND USE FOR THE SAME | UNIV FUDAN (CN) | 2020-07-30 | — | — | US | disclosed |
| US-10647665-B2 | Biaryl urea derivative or salt thereof and preparation process and use for the same | FUDAN UNIVERSITY (CN) | 2020-05-12 | — | — | US | disclosed |
| US-20190248737-A1 | BIARYL UREA DERIVATIVE OR SALT THEREOF AND PREPARATION PROCESS AND USE FOR THE SAME | FUDAN UNIVERSITY (CN) | 2019-08-15 | — | — | US | disclosed |
| EP-3476829-A1 | BIARYL UREA DERIVATIVE OR SALT THEREOF, AND MANUFACTURING AND APPLICATION OF SAME | Fudan University (CN) | 2019-05-01 | — | — | EP | disclosed |
| CN-103641709-B | The ketone enol replaced by haloalkyl methylene phenyl | 拜耳知识产权有限责任公司 | 2017-08-25 | — | — | CN | disclosed |
| WO-2015011252-A1 | PYRIMIDINE-PYRIDINONE SERINE/THREONINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-01-29 | — | — | WO | disclosed |
| US-7923573-B2 | Benzene compound having 2 or more substituents | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-04-12 | — | — | US | disclosed |
| US-20100267964-A1 | N-HETEROCYCLYLPHENYL-SUBSTITUTED CYCLIC KETOENOLS | FISCHER REINER | 2010-10-21 | — | — | US | disclosed |
| US-7776791-B2 | N-heterocyclyl phenyl-substituted cyclic ketoenols | BAYER CROPSCIENCE AG (DE) | 2010-08-17 | — | — | US | disclosed |
| US-20060166829-A1 | N-Heterocycl phenyl-substituted cyclic ketoenols | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2006-07-27 | — | — | US | disclosed |
| US-6759548-B2 | PESTICIDES AND HERBICIDES. PHENYL-SUBSTITUTED CYCLIC KETOENOLS, A PLURALITY OF PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION | BAYER AKTIENGESELLSCHAFT (DE) | 2004-07-06 | — | — | US | disclosed |
| US-20030144504-A1 | Pesticides and herbicides. phenyl-substituted cyclic ketoenols, a plurality of processes and intermediates for their preparation | FISCHER REINER (DE) | 2003-07-31 | — | — | US | disclosed |
| US-6469196-B2 | PESTICIDES AND WEEDKILLERS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-10-22 | — | — | US | disclosed |
| US-20020022575-A1 | Dialkyl-halogenophenyl-substituted ketoenols | FISCHER REINER (DE) | 2002-02-21 | — | — | US | disclosed |
| US-6251830-B1 | PESTICIDES AND HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-06-26 | — | — | US | disclosed |
| US-5994274-A | Dialkyl phenyl halide-substituted keto-enols for use as herbicides and pesticides | BAYER AKTIENGESELLSCHAFT (DE) | 1999-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144504-A1 | Pesticides and herbicides. phenyl-substituted cyclic ketoenols, a plurality of processes and intermediates for their preparation | DDT, CYP8B1, CYP1A1 | GRM1 717/4885MEN1 4412/4885KMT2A 1001/4885 |
| US-20100267964-A1 | N-HETEROCYCLYLPHENYL-SUBSTITUTED CYCLIC KETOENOLS | CYP17A1, CCNY, CCNE2 | GRM1 4429/4885MEN1 2806/4885KMT2A 1673/4885 |
| US-20060166829-A1 | N-Heterocycl phenyl-substituted cyclic ketoenols | WEE1, KCNE1, CCNE1 | GRM1 2482/4885MEN1 4715/4885KMT2A 1063/4885 |
| US-20200239411-A1 | BIARYL UREA DERIVATIVE OR SALT THEREOF AND PREPARATION PROCESS AND USE FOR THE SAME | RORC, RORB, RORA | GRM1 3626/4885MEN1 4267/4885KMT2A 1108/4885 |
| US-20020022575-A1 | Dialkyl-halogenophenyl-substituted ketoenols | DDT, CYP2E1, CYP8B1 | GRM1 603/4885MEN1 3842/4885KMT2A 789/4885 |
| US-20190248737-A1 | BIARYL UREA DERIVATIVE OR SALT THEREOF AND PREPARATION PROCESS AND USE FOR THE SAME | RORC, RORB, RORA | GRM1 3781/4885MEN1 4328/4885KMT2A 1157/4885 |
| US-10647665-B2 | Biaryl urea derivative or salt thereof and preparation process and use for the same | RORC, RORB, RORA | GRM1 3781/4885MEN1 4328/4885KMT2A 1157/4885 |
| US-10851050-B2 | Biaryl urea derivative or salt thereof and preparation process and use for the same | RORC, RORB, RORA | GRM1 3626/4885MEN1 4267/4885KMT2A 1108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.