Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16797142 | 0.88 | ALDH1A1 (0.51) | GAAPOLBTDP1SMN1; SMN2KDM4E | |
| SCHEMBL28098678 | 0.82 | GAA (0.46) | GAAPOLBTDP1SMN1; SMN2KDM4E | |
| SCHEMBL8758926 | 0.75 | ALDH1A1 (0.60) | GAAPOLBTDP1SMN1; SMN2KDM4E | |
| SCHEMBL25791893 | 0.74 | CA1 (0.51) | GAAPOLBSMN1; SMN2KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL16797134 | 0.73 | PTGER4 (0.50) | GAAPOLBSMN1; SMN2KDM4ELMNA | |
| SCHEMBL8315129 | 0.70 | WDR5 (0.52) | GAAPOLBTDP1SMN1; SMN2KDM4E | |
| SCHEMBL826800 | 0.70 | LMNA (0.59) | SMN1; SMN2KDM4ELMNARAB9ANPC1 | |
| SCHEMBL16797151 | 0.69 | ALDH1A1 (0.58) | GAASMN1; SMN2LMNARAB9ANPC1 | |
| SCHEMBL1147208 | 0.68 | CA12 (0.61) | POLBSMN1; SMN2KDM4ELMNARAB9A | |
| SCHEMBL29823214 | 0.68 | CA12 (0.61) | POLBSMN1; SMN2KDM4ELMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080090-B1 | BICYCLIC HETEROARYL INDOLE ANALOGUES USEFUL AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS SA (CH) | 2018-01-31 | — | — | EP | disclosed |
| US-9682977-B2 | Bicyclic heteroaryl indole analogues useful as ROR gamma modulators | GLENMARK PHARMACEUTICALS S.A. (CH) | 2017-06-20 | — | — | US | disclosed |
| US-20160326163-A1 | BICYCLIC HETEROARYL INDOLE ANALOGUES USEFUL AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2016-11-10 | — | — | US | disclosed |
| EP-3080090-A1 | BICYCLIC HETEROARYL INDOLE ANALOGUES USEFUL AS ROR GAMMA MODULATORS | Glenmark Pharmaceuticals S.A. (CH) | 2016-10-19 | — | — | EP | disclosed |
| WO-2015087234-A1 | BICYCLIC HETEROARYL INDOLE ANALOGUES USEFUL AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160326163-A1 | BICYCLIC HETEROARYL INDOLE ANALOGUES USEFUL AS ROR GAMMA MODULATORS | RORA, RORB, RORC | GAA 4445/4885POLB 2381/4885TDP1 4119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.