Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.37 |
| ▸ | TGM2 | P21980 | 5/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16798099 | 0.86 | TGM2 (0.33) | JAK3TGM2KDRITK | |
| SCHEMBL16798100 | 0.74 | HTR7 (0.35) | JAK3BTKKDRITK | |
| SCHEMBL16766732 | 0.73 | NOS1 (0.40) | JAK3TGM2BTKITKMTNR1A | |
| SCHEMBL16798291 | 0.71 | BTK (0.43) | JAK3BTK | |
| SCHEMBL16765982 | 0.70 | BTK (0.52) | JAK3BTK | |
| SCHEMBL16798041 | 0.69 | BTK (0.34) | BTKKDR | |
| SCHEMBL16766051 | 0.65 | CKS1B (0.47) | TGM2BTKKDRITK | |
| SCHEMBL8444160 | 0.63 | MTNR1A (0.51) | JAK3TGM2MTNR1AMTNR1B | |
| SCHEMBL27346 | 0.57 | ALDH1A1 (0.56) | TGM2 | |
| SCHEMBL12301856 | 0.57 | ZDHHC20 (0.52) | TGM2MTNR1AMTNR1BCD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077384-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS WITH ELECTROPHILIC FUNCTIONALITY | F. Hoffmann-La Roche AG (CH) | 2016-10-12 | — | — | EP | disclosed |
| WO-2015082583-A1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS WITH ELECTROPHILIC FUNCTIONALITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-06-11 | — | — | WO | disclosed |