Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 5/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 3/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.39 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.39 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CCL2 | P13500 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14744272 | 0.86 | CYP26A1 (0.47) | KIF11CA2PTGDR2ALDH1A1RORC | |
| SCHEMBL30116472 | 0.86 | CYP26A1 (0.47) | KIF11CA2PTGDR2ALDH1A1RORC | |
| SCHEMBL16879775 | 0.85 | CA2 (0.51) | CA2EPHX2NR1H4CYP26A1CYP26B1 | |
| SCHEMBL16879788 | 0.84 | EPHX2 (0.41) | KIF11CA2EPHX2NR1H4ALDH1A1 | |
| SCHEMBL16880028 | 0.83 | LOX (0.39) | KIF11CA2EPHX2NR1H4ALDH1A1 | |
| SCHEMBL23488069 | 0.82 | KIF11 (0.42) | KIF11CA2PTGDR2EPHX2NR1H4 | |
| SCHEMBL16880042 | 0.82 | CA2 (0.41) | KIF11CA2PTGDR2EPHX2NR1H4 | |
| SCHEMBL14744197 | 0.81 | GAA (0.47) | PTGDR2GAA | |
| SCHEMBL28512005 | 0.80 | CA2 (0.47) | KIF11CA2PTGDR2EPHX2NR1H4 | |
| SCHEMBL19360365 | 0.80 | PSIP1 (0.52) | KIF11CA2PTGDR2EPHX2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015101928-A1 | FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-07-09 | — | — | WO | claimed |
| WO-2015083130-A1 | FUSED PYRIDINE AND PYRIMIDINE DERIVATIVES AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-06-11 | — | — | WO | claimed |
| US-20220125780-A1 | SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS | AURIGENE ONCOLOGY LIMITED (IN) | 2022-04-28 | — | — | US | disclosed |
| US-11229636-B2 | Substituted tetrahydroquinolinone compounds as ROR gamma modulators | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2022-01-25 | — | — | US | disclosed |
| EP-3845526-A1 | METHOD FOR THE PREPARATION OF TETRAHYDROQUINOLINONE COMPOUNDS HAVING ROR-GAMMA MODULATING ACTIVITY | Aurigene Discovery Technologies Limited (IN) | 2021-07-07 | — | — | EP | disclosed |
| US-20210113551-A9 | SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2021-04-22 | — | — | US | disclosed |
| EP-3294713-B1 | SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECH LTD (IN) | 2021-02-17 | — | — | EP | disclosed |
| US-20180200247-A1 | Substituted Tetrahydroquinolinone Compounds as ROR Gamma Modulators | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2018-07-19 | — | — | US | disclosed |
| US-20180200247-A1 | Substituted Tetrahydroquinolinone Compounds as ROR Gamma Modulators | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2018-07-19 | — | — | US | disclosed |
| WO-2016185342-A1 | SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2016-11-24 | — | — | WO | disclosed |
| WO-2015101928-A1 | FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-07-09 | — | — | WO | disclosed |
| WO-2015101928-A1 | FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-07-09 | — | — | WO | disclosed |
| WO-2015083130-A1 | FUSED PYRIDINE AND PYRIMIDINE DERIVATIVES AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-06-11 | — | — | WO | disclosed |
| WO-2015083130-A1 | FUSED PYRIDINE AND PYRIMIDINE DERIVATIVES AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11229636-B2 | Substituted tetrahydroquinolinone compounds as ROR gamma modulators | RORC, RORA, RORB | KIF11 1864/4885CA2 4024/4885PTGDR2 401/4885 |
| US-20180200247-A1 | Substituted Tetrahydroquinolinone Compounds as ROR Gamma Modulators | RORC, RORA, RORB | KIF11 1864/4885CA2 4024/4885PTGDR2 401/4885 |
| US-20210113551-A9 | SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS | RORC, RORA, RORB | KIF11 1864/4885CA2 4024/4885PTGDR2 401/4885 |
| US-20220125780-A1 | SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS | RORC, RORA, RORB | KIF11 1864/4885CA2 4024/4885PTGDR2 401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.