SCHEMBL1680022

SCHEMBL1680022

Ic1cncc(OC[C@@H]2CCN2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 1.00
CHRNA4 P43681 2/20 1.00
KDM4E B2RXH2 1/20 1.00
CYP1A2 P05177 1/20 1.00
CYP2D6 P10635 1/20 1.00
CYP2C9 P11712 1/20 1.00
CYP2C19 P33261 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL29615776 0.98 CHRNB2 (0.97) CHRNB2CHRNA4KDM4ECYP1A2CYP2D6
SCHEMBL2441396 0.81 CHRNB2 (0.68) CHRNB2CHRNA4KDM4ECYP1A2CYP2D6
SCHEMBL7411369 0.81 CHRNB2 (0.68) CHRNB2CHRNA4KDM4ECYP1A2CYP2D6
SCHEMBL15031431 0.81 CHRNB2 (0.68) CHRNB2CHRNA4KDM4ECYP1A2CYP2D6
SCHEMBL4111623 0.81 CHRNB2 (0.68) CHRNB2CHRNA4KDM4ECYP1A2CYP2D6
SCHEMBL3224827 0.81 CHRNB2 (0.68) CHRNB2CHRNA4KDM4ECYP1A2CYP2D6
SCHEMBL7414932 0.81 CHRNB2 (0.68) CHRNB2CHRNA4KDM4ECYP1A2CYP2D6
SCHEMBL7409974 0.81 CHRNB2 (0.68) CHRNB2CHRNA4KDM4ECYP1A2CYP2D6
SCHEMBL2437117 0.81 CHRNB2 (0.68) CHRNB2CHRNA4KDM4ECYP1A2CYP2D6
SCHEMBL15805078 0.81 CHRNB2 (0.68) CHRNB2CHRNA4KDM4ECYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240173318-A1 DRY EYE TREATMENTS OYSTER POINT PHARMA INC (US) 2024-05-30 US claimed
US-11679103-B2 Multi-targeting agents for Alzheimer's disease therapy THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-06-20 US claimed
US-12576080-B2 Use of varenicline for treating ocular conditions Oyster Point Pharma, Inc. 2026-03-17 US disclosed
US-20250275963-A1 DRY EYE TREATMENTS OYSTER POINT PHARMA INC (US) 2025-09-04 US disclosed
US-20250255865-A1 METHODS OF TREATING OCULAR CONDITIONS OYSTER POINT PHARMA INC (US) 2025-08-14 US disclosed
US-20250235449-A1 METHODS OF TREATING OCULAR CONDITIONS OYSTER POINT PHARMA INC (US) 2025-07-24 US disclosed
EP-3848028-B9 METHODS OF TREATING OCULAR CONDITIONS OYSTER POINT PHARMA INC (US) 2024-10-16 EP disclosed
EP-4413974-A2 METHODS OF TREATING OCULAR CONDITIONS Oyster Point Pharma, Inc. (US) 2024-08-14 EP disclosed
CN-111956650-B Methods of treating ocular conditions 奥伊斯特普安生物制药公司 2024-06-04 CN disclosed
US-20240173318-A1 DRY EYE TREATMENTS OYSTER POINT PHARMA INC (US) 2024-05-30 US disclosed
EP-3848028-B1 METHODS OF TREATING OCULAR CONDITIONS OYSTER POINT PHARMA INC (US) 2024-05-29 EP disclosed
US-20160106746-A1 PHARMACEUTICAL FORMULATIONS FOR TREATING OCULAR CONDITIONS OYSTER POINT PHARMA INC. 2016-04-21 US disclosed
US-20160106744-A1 METHODS OF INCREASING TEAR PRODUCTION OYSTER POINT PHARMA INC. 2016-04-21 US disclosed
US-20160106665-A1 OCULAR DISCOMFORT OYSTER POINT PHARMA INC. 2016-04-21 US disclosed
US-20160106745-A1 DRY EYE TREATMENTS OYSTER POINT PHARMA INC. 2016-04-21 US disclosed
US-20150366523-A1 NEURONAL IMAGING AND TREATMENT TYLERTON INTERNATIONAL HOLDINGS INC. (VG) 2015-12-24 US disclosed
US-20150366523-A1 NEURONAL IMAGING AND TREATMENT TYLERTON INTERNATIONAL HOLDINGS INC. (VG) 2015-12-24 US disclosed
WO-2014115152-A1 NEURONAL IMAGING AND TREATMENT TYLERTON INTERNATIONAL HOLDINGS INC. (VG) 2014-07-31 WO disclosed
US-8729103-B2 Silent desensitizers of neuronal nAChR and methods of use thereof GEORGETOWN UNIVERSITY (US) 2014-05-20 US disclosed
WO-2011040574-A1 METHOD FOR PRODUCING AZETIDINYLMETHOXYPYRIDINE DERIVATIVE AND USE OF AZETIDINYLMETHOXYPYRIDINE DERIVATIVE 国立大学法人京都大学 (JP) 2011-04-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12576080-B2 Use of varenicline for treating ocular conditions PDE6D, PDE11A, PDE10A CHRNB2 218/4885CHRNA4 301/4885KDM4E 2278/4885
US-20250235449-A1 METHODS OF TREATING OCULAR CONDITIONS CYSLTR2, ASAH2, AQP4 CHRNB2 396/4885CHRNA4 742/4885KDM4E 4445/4885
US-20160106665-A1 OCULAR DISCOMFORT PDE6H, PDE6D, TRPA1 CHRNB2 1498/4885CHRNA4 2068/4885KDM4E 4751/4885
US-20250275963-A1 DRY EYE TREATMENTS PDE6D, CRYAB, ALDH1A2 CHRNB2 1787/4885CHRNA4 2137/4885KDM4E 4549/4885
US-20240173318-A1 DRY EYE TREATMENTS PDE6D, CRYAB, ALDH1A2 CHRNB2 1787/4885CHRNA4 2137/4885KDM4E 4549/4885
US-20160106744-A1 METHODS OF INCREASING TEAR PRODUCTION LIPA, PGA5, UTRN CHRNB2 2353/4885CHRNA4 3542/4885KDM4E 4828/4885
US-20250255865-A1 METHODS OF TREATING OCULAR CONDITIONS CYSLTR2, ASAH2, AQP4 CHRNB2 396/4885CHRNA4 742/4885KDM4E 4445/4885
US-20160106746-A1 PHARMACEUTICAL FORMULATIONS FOR TREATING OCULAR CONDITIONS EYA3, EYA2, LIPA CHRNB2 2572/4885CHRNA4 3615/4885KDM4E 4379/4885
US-20160106745-A1 DRY EYE TREATMENTS PDE6D, CRYAB, ALDH1A2 CHRNB2 1787/4885CHRNA4 2137/4885KDM4E 4549/4885
US-11679103-B2 Multi-targeting agents for Alzheimer's disease therapy BACE2, PSEN2, APP CHRNB2 83/4885CHRNA4 488/4885KDM4E 3774/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.