Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | ANPEP | P15144 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | LAP3 | P28838 | 1/20 | 0.41 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8512023 | 0.84 | LMNA (0.60) | CTSKCTSSCHRNA7LMNACYP2D6 | |
| SCHEMBL8512028 | 0.84 | LMNA (0.60) | CTSKCTSSCHRNA7LMNACYP2D6 | |
| SCHEMBL8512022 | 0.84 | LMNA (0.60) | CTSKCTSSCHRNA7LMNACYP2D6 | |
| SCHEMBL6347304 | 0.84 | MMP2 (0.53) | CTSKCTSSS1PR3MMP2MMP9 | |
| SCHEMBL27770063 | 0.84 | MMP2 (0.53) | CTSKCTSSS1PR3MMP2MMP9 | |
| SCHEMBL9290260 | 0.83 | CHRM2 (0.61) | CTSKCTSSCHRM2CHRM1CHRM4 | |
| Iodide SCHEMBL8509292 | 0.83 | PABPC1 (0.63) | CTSKCTSSCHRM2CHRM1CHRM4 | |
| SCHEMBL16789062 | 0.81 | CTSS (0.49) | CTSKCTSSMMP2MMP9ANPEP | |
| SCHEMBL16789065 | 0.81 | CTSK (0.51) | CTSKCTSSS1PR3MMP2MMP9 | |
| SCHEMBL30863885 | 0.80 | CTSS (0.48) | CTSKCTSSS1PR3MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077385-B1 | HETEROARYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES | CHIESI FARM SPA (IT) | 2017-10-04 | — | — | EP | disclosed |
| WO-2015082616-A1 | HETEROARYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-06-11 | — | — | WO | disclosed |