SCHEMBL16812971

SCHEMBL16812971

COc1ccc2[nH]c3c(c2c1)NC(=O)CN=C3c1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.62
HTR7 P34969 3/20 0.50
CHRM4 P08173 2/20 0.50
DRD2 P14416 2/20 0.50
HPGD P15428 4/20 0.49
GSK3B P49841 3/20 0.47
CCNB2 O95067 2/20 0.47
CDK1 P06493 2/20 0.47
CCNB1 P14635 2/20 0.47
CDK5 Q00535 2/20 0.47
CDK5R1 Q15078 2/20 0.47
CCNB3 Q8WWL7 2/20 0.47
ABCG2 Q9UNQ0 1/20 0.47
HTR1A P08908 1/20 0.47
HTR1D P28221 1/20 0.47
SLC6A4 P31645 1/20 0.47
HTR5A P47898 1/20 0.47
HTR6 P50406 1/20 0.47
EGFR P00533 1/20 0.45
GSK3A P49840 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16812980 0.87 ALDH1A1 (0.52) ALDH1A1HTR7CHRM4DRD2HPGD
SCHEMBL16812979 0.87 CHRM4 (0.59) ALDH1A1HTR7CHRM4DRD2HPGD
SCHEMBL16813041 0.85 HPGD (0.47) ALDH1A1HPGDGSK3BCCNB2CDK1
SCHEMBL16813014 0.84 CHRM4 (0.51) ALDH1A1HTR7CHRM4DRD2GSK3B
SCHEMBL16813021 0.84 CHRM4 (0.51) ALDH1A1HTR7CHRM4DRD2HPGD
SCHEMBL16812977 0.83 GABRA1 (0.51) ALDH1A1HPGDHTR1AKDM4EMAPT
SCHEMBL16813036 0.83 CNR1 (0.56) ALDH1A1GSK3BCCNB2CDK1CCNB1
SCHEMBL16813042 0.83 ALDH1A1 (0.46) ALDH1A1HPGDGSK3BCCNB2CDK1
SCHEMBL16796608 0.80 ALDH1A1 (0.47) ALDH1A1HTR7CHRM4DRD2HPGD
SCHEMBL16813010 0.80 ALDH1A1 (0.47) ALDH1A1HTR7CHRM4DRD2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015088565-A1 P2X4 RECEPTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF SUNOVION PHARMACEUTICALS INC. (US) 2015-06-18 WO disclosed