Sugi Predict

Sugi Predict / Compounds / SCHEMBL1685158

SCHEMBL1685158

SCHEMBL1685158

Clc1ncc(I)c2nccn12

nearest known ligand 0.33

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ CCNE1 P24864 2/20 0.33
▸ CDK2 P24941 2/20 0.33
▸ CCNE2 O96020 1/20 0.33
▸ GRIN2D O15399 1/20 0.33
▸ GRIN3B O60391 1/20 0.33
▸ GRIA1 P42261 1/20 0.33
▸ GRIA2 P42262 1/20 0.33
▸ GRIA3 P42263 1/20 0.33
▸ GRIA4 P48058 1/20 0.33
▸ GRIN1 Q05586 1/20 0.33
▸ GRIN2A Q12879 1/20 0.33
▸ GRIN2B Q13224 1/20 0.33
▸ GRIN2C Q14957 1/20 0.33
▸ GRIN3A Q8TCU5 1/20 0.33
▸ EGLN2 Q96KS0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28957507 0.79 GRIN2D (0.38) CCNE1CDK2CCNE2GRIN2DGRIN3B
SCHEMBL21062848 0.76 AXL (0.44) CCNE1CDK2CCNE2GRIN2DGRIN3B
SCHEMBL21287178 0.76 CCNE1 (0.34) CCNE1CDK2CCNE2
SCHEMBL22521326 0.76 ADORA2A (0.39) —
SCHEMBL21986319 0.76 CYP2E1 (0.34) —
SCHEMBL21287497 0.76 AXL (0.32) —
SCHEMBL22814529 0.76 L3MBTL1 (0.34) CCNE1CDK2CCNE2GRIN2DGRIN3B
SCHEMBL1685106 0.72 CCNE1 (0.36) CCNE1CDK2CCNE2GRIN2DGRIN3B
SCHEMBL21287498 0.71 GRIN2D (0.32) GRIN2DGRIN3BGRIA1GRIA2GRIA3
SCHEMBL23709296 0.68 EED (0.40) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12441743-B2 Spiro aromatic ring compound and use thereof ETERN BIOPHARMA (SHANGHAI) CO., LTD. (CN) 2025-10-14 — — US disclosed
CN-115697986-B Isotopically substituted spiro aromatic compounds and uses thereof 上海奕拓医药科技有限责任公司 2024-10-25 — — CN disclosed
CN-118359642-A Spiro aromatic ring compound and application thereof 上海奕拓医药科技有限责任公司 2024-07-19 — — CN disclosed
CN-118206550-A SHP2 inhibitor and application thereof 江苏威凯尔医药科技有限公司 2024-06-18 — — CN disclosed
CN-111566104-B Spiro aromatic ring compound and application thereof 上海奕拓医药科技有限责任公司 2024-05-17 — — CN disclosed
US-20240140931-A1 TRICYCLIC COMPOUNDS AND USES THEREOF HUTCHMED LIMITED (CN) 2024-05-02 — — US disclosed
EP-3753941-B1 PYRIMIDINE-FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF SHANGHAI BLUERAY BIOPHARMA CO LTD (CN) 2024-05-01 — — EP disclosed
US-20240116949-A1 SPIRO AROMATIC RING COMPOUND AND USE THEREOF ETERN BIOPHARMA SHANGHAI CO LTD (CN) 2024-04-11 — — US disclosed
CN-114539223-B Aryl-containing aza-seven-membered ring compound and preparation method and application thereof 中国药科大学 2024-04-09 — — CN disclosed
CN-115448923-B Pyrimidine-fused ring compound, preparation method and application thereof 上海青煜医药科技有限公司 2024-03-22 — — CN disclosed
US-20200317695-A1 SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF ETERN BIOPHARMA (SHANGHAI) CO., LTD. (CN) 2020-10-08 — — US disclosed
US-20200317695-A1 SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF ETERN BIOPHARMA (SHANGHAI) CO., LTD. (CN) 2020-10-08 — — US disclosed
EP-3712151-A1 SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF Etern Biopharma (Shanghai) Co., Ltd. (CN) 2020-09-23 — — EP disclosed
EP-3712151-A1 SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF Etern Biopharma (Shanghai) Co., Ltd. (CN) 2020-09-23 — — EP disclosed
CN-111592525-A Spiro aromatic ring compound and application thereof 上海奕拓医药科技有限责任公司 2020-08-28 — — CN disclosed
CN-111566104-A Spiro aromatic ring compound and application thereof 上海奕拓医药科技有限责任公司 2020-08-21 — — CN disclosed
CN-111138412-A Spiro aromatic ring compound and application thereof 上海奕拓医药科技有限责任公司 2020-05-12 — — CN disclosed
CN-110655520-A Pyrimido-cyclic compounds, process for their preparation and their use 上海青煜医药科技有限公司 2020-01-07 — — CN disclosed
WO-2019158019-A1 PYRIMIDINE-FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 上海青煜医药科技有限公司 2019-08-22 — — WO disclosed
US-20120010206-A1 IMIDAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES GALAPAGOS N. V. (BE) 2012-01-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240116949-A1 SPIRO AROMATIC RING COMPOUND AND USE THEREOF PTPN1, PTPN11, PTPN5 CCNE1 1974/4885CDK2 543/4885CCNE2 2790/4885
US-12441743-B2 Spiro aromatic ring compound and use thereof PTPN1, PTPN11, PTPN5 CCNE1 1974/4885CDK2 543/4885CCNE2 2790/4885
US-20120010206-A1 IMIDAZOLOPYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES COL2A1, MMP1, COL1A1 CCNE1 2446/4885CDK2 321/4885CCNE2 2964/4885
US-20200317695-A1 SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF PTPN1, PTPN11, PTPN5 CCNE1 1893/4885CDK2 556/4885CCNE2 2652/4885
US-20240140931-A1 TRICYCLIC COMPOUNDS AND USES THEREOF CYP2C19, CYP3A7, CYP11B2 CCNE1 1392/4885CDK2 1935/4885CCNE2 1395/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.