Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.36 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20090738 | 1.00 | ALDH1A1 (0.45) | ALDH1A1CYP1A2CYP3A4CYP2C19CHRM1 | |
| SCHEMBL7849306 | 0.93 | ALDH1A1 (0.49) | ALDH1A1CYP1A2CYP3A4CYP2C19CHRM1 | |
| SCHEMBL19423892 | 0.84 | ALDH1A1 (0.38) | ALDH1A1CYP1A2CYP3A4CYP2C19CHRM1 | |
| SCHEMBL15851267 | 0.78 | ALDH1A1 (0.43) | ALDH1A1CYP1A2CYP3A4CYP2C19CHRM1 | |
| SCHEMBL15851271 | 0.78 | ALDH1A1 (0.43) | ALDH1A1CYP1A2CYP3A4CYP2C19CHRM1 | |
| SCHEMBL16866231 | 0.78 | LMNA (0.52) | ALDH1A1CYP1A2CYP3A4CYP2C19CHRM1 | |
| SCHEMBL18347994 | 0.78 | ALDH1A1 (0.43) | ALDH1A1CYP1A2CYP3A4CYP2C19CHRM1 | |
| SCHEMBL16920563 | 0.78 | LMNA (0.52) | ALDH1A1CYP1A2CYP3A4CYP2C19CHRM1 | |
| SCHEMBL24735809 | 0.77 | RECQL (0.50) | ALDH1A1CYP1A2CYP3A4CYP2C19CHRNB2 | |
| SCHEMBL15196701 | 0.77 | ALDH1A1 (0.42) | ALDH1A1CYP1A2CYP3A4CYP2C19CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230278998-A1 | Compound containing structure of a five-membered heteroaromatic ring, pharmaceutical compositions thereof and applications thereof | 280 BIO, INC. (US) | 2023-09-07 | — | — | US | disclosed |
| US-10005792-B2 | Aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived PRMT5-inhibitors | CTXT PTY. LTD. (AU) | 2018-06-26 | — | — | US | disclosed |
| US-9988391-B2 | TBK/IKK inhibitor compounds and uses thereof | MERCK PATENT GMBH (DE) | 2018-06-05 | — | — | US | disclosed |
| US-9988391-B2 | TBK/IKK inhibitor compounds and uses thereof | MERCK PATENT GMBH (DE) | 2018-06-05 | — | — | US | disclosed |
| US-20180111934-A1 | HETEROCYCLIC MORPHINAN DERIVATIVES AND USE THEREOF | PURDUE PHARMA L.P. | 2018-04-26 | — | — | US | disclosed |
| US-20180111934-A1 | HETEROCYCLIC MORPHINAN DERIVATIVES AND USE THEREOF | PURDUE PHARMA L.P. | 2018-04-26 | — | — | US | disclosed |
| US-20170313713-A1 | AMINOINDANE-, AMINOTETRAHYDRONAPHTHALENE- AND AMINOBENZOCYCLOBUTANE-DERIVED PRMT5-INHIBITORS | CTXT PTY. LTD. (AU) | 2017-11-02 | — | — | US | disclosed |
| US-20170298075-A1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | CTXT PTY. LTD. (AU) | 2017-10-19 | — | — | US | disclosed |
| US-20170283407-A1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | CTXT PTY. LTD. (AU) | 2017-10-05 | — | — | US | disclosed |
| US-20160376283-A1 | TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2016-12-29 | — | — | US | disclosed |
| US-9403824-B2 | Pyridonemorphinan analogs and biological activity on opioid receptors | PURDUE PHARMA L.P. (US) | 2016-08-02 | — | — | US | disclosed |
| US-9340542-B2 | Propellane-based compounds and the use thereof | PURDUE PHARMA L.P. (US) | 2016-05-17 | — | — | US | disclosed |
| US-20150203494-A1 | PYRIDONEMORPHINAN ANALOGS AND BIOLOGICAL ACTIVITY ON OPIOID RECEPTORS | PURDUE PHARMA L.P. | 2015-07-23 | — | — | US | disclosed |
| US-20150183787-A1 | PROPELLANE-BASED COMPOUNDS AND THE USE THEREOF | PURDUE PHARMA L.P. | 2015-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10005792-B2 | Aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived PRMT5-inhibitors | PRMT5, PRMT1, PRMT3 | ALDH1A1 2987/4885CYP1A2 767/4885CYP3A4 1248/4885 |
| US-20180111934-A1 | HETEROCYCLIC MORPHINAN DERIVATIVES AND USE THEREOF | OPRM1, OPRL1, OPRD1 | ALDH1A1 626/4885CYP1A2 82/4885CYP3A4 80/4885 |
| US-20150183787-A1 | PROPELLANE-BASED COMPOUNDS AND THE USE THEREOF | OPRL1, OPRK1, OPRD1 | ALDH1A1 214/4885CYP1A2 191/4885CYP3A4 402/4885 |
| US-20170313713-A1 | AMINOINDANE-, AMINOTETRAHYDRONAPHTHALENE- AND AMINOBENZOCYCLOBUTANE-DERIVED PRMT5-INHIBITORS | PRMT5, PRMT1, PRMT3 | ALDH1A1 2910/4885CYP1A2 820/4885CYP3A4 1299/4885 |
| US-20150203494-A1 | PYRIDONEMORPHINAN ANALOGS AND BIOLOGICAL ACTIVITY ON OPIOID RECEPTORS | OPRM1, OPRK1, OPRL1 | ALDH1A1 704/4885CYP1A2 204/4885CYP3A4 460/4885 |
| US-20170298075-A1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | PRMT5, PRMT1, PRMT3 | ALDH1A1 4190/4885CYP1A2 1959/4885CYP3A4 1562/4885 |
| US-20170283407-A1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | PRMT5, PRMT3, PRMT1 | ALDH1A1 4354/4885CYP1A2 1990/4885CYP3A4 1593/4885 |
| US-20230278998-A1 | Compound containing structure of a five-membered heteroaromatic ring, pharmaceutical compositions thereof and applications thereof | PARG, CYP3A5, CYP11B1 | ALDH1A1 749/4885CYP1A2 41/4885CYP3A4 20/4885 |
| US-20160376283-A1 | TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF | NFKBIA, TBKBP1, TBK1 | ALDH1A1 4646/4885CYP1A2 3277/4885CYP3A4 2421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.