SCHEMBL16884397

SCHEMBL16884397

NCCSC1=CC(=O)c2ccccc2C1=O

nearest known ligand 0.71

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
SOAT1 P35610 13/20 0.71
S100A4 P26447 5/20 0.71
MAP2K7 O14733 3/20 0.65
CDC25A P30304 3/20 0.65
CDC25B P30305 3/20 0.65
STAT3 P40763 1/20 0.47
ELANE P08246 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7106792 0.83 SOAT1 (1.00) SOAT1S100A4MAP2K7CDC25ACDC25B
SCHEMBL2599403 0.83 S100A4 (1.00) SOAT1S100A4MAP2K7CDC25ACDC25B
SCHEMBL9270311 0.81 S100A4 (0.76) SOAT1S100A4MAP2K7CDC25ACDC25B
SCHEMBL2599427 0.80 SOAT1 (1.00) SOAT1S100A4MAP2K7CDC25ACDC25B
SCHEMBL9267240 0.80 S100A4 (0.69) SOAT1S100A4MAP2K7CDC25ACDC25B
SCHEMBL2599351 0.79 S100A4 (1.00) SOAT1S100A4MAP2K7CDC25ACDC25B
SCHEMBL15732841 0.79 SOAT1 (1.00) SOAT1S100A4MAP2K7CDC25ACDC25B
SCHEMBL2599376 0.79 SOAT1 (1.00) SOAT1S100A4MAP2K7CDC25ACDC25B
SCHEMBL10034769 0.79 P4HB (0.70) S100A4STAT3
SCHEMBL15732984 0.78 SOAT1 (1.00) SOAT1S100A4MAP2K7CDC25ACDC25B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11773111-B1 Selective 5-LO inhibitors for the treatment of bronchial asthma King Faisal University (SA) 2023-10-03 US disclosed
US-11724991-B1 Selective 5-LO inhibitors for the treatment of bronchial asthma King Faisal University (SA) 2023-08-15 US disclosed
US-20150192852-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR AND PLATE MAKING METHOD FUJIFILM CORPORATION (JP) 2015-07-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11773111-B1 Selective 5-LO inhibitors for the treatment of bronchial asthma ALOX5, LTC4S, NOX5 SOAT1 1139/4885S100A4 4476/4885MAP2K7 921/4885
US-11724991-B1 Selective 5-LO inhibitors for the treatment of bronchial asthma ALOX5, LTC4S, NOX5 SOAT1 1175/4885S100A4 4257/4885MAP2K7 932/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.