Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TAS2R8 | Q9NYW2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15105309 | 0.76 | TAS2R8 (0.64) | TAS2R8 | |
| SCHEMBL16990135 | 0.73 | TAS2R8 (0.64) | TAS2R8 | |
| SCHEMBL22957172 | 0.70 | SIGMAR1 (0.50) | L3MBTL1LMNAHTR2CSIGMAR1PKM | |
| SCHEMBL14949699 | 0.68 | TAS2R8 (0.65) | TAS2R8 | |
| SCHEMBL27460680 | 0.66 | L3MBTL1 (0.43) | L3MBTL1LMNAMAPTPKMNPSR1 | |
| SCHEMBL301699 | 0.64 | SIGMAR1 (0.81) | DRD4LMNASIGMAR1 | |
| SCHEMBL126155 | 0.64 | HTR2C (0.50) | DRD4DRD2DRD3LMNAMAPT | |
| SCHEMBL20029226 | 0.63 | SCD (0.62) | LMNAMAPTPKMNPSR1USP2 | |
| SCHEMBL671242 | 0.62 | TSHR (0.63) | L3MBTL1LMNAPKMUSP2SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL30282920 | 0.62 | LMNA (0.45) | L3MBTL1LMNASIGMAR1PKMNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3104712-A1 | IMPROVED PROCESS FOR THE SYNTHESIS OF SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES | Senomyx, Inc. (US) | 2016-12-21 | — | — | EP | disclosed |
| WO-2015123282-A1 | IMPROVED PROCESS FOR THE SYNTHESIS OF SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES | FOTSING JOSEPH R (US) | 2015-08-20 | — | — | WO | disclosed |