SCHEMBL1701352

SCHEMBL1701352

O=CC(Br)c1ccc(Oc2ccccc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 3/20 0.46
TSHR P16473 1/20 0.46
SRD5A2 P31213 2/20 0.46
NR1H2 P55055 1/20 0.42
BAX Q07812 1/20 0.42
MAOA P21397 1/20 0.42
ACACB O00763 1/20 0.41
ACACA Q13085 1/20 0.41
GSTP1 P09211 1/20 0.40
SOS1 Q07889 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA9 Q16790 1/20 0.40
PARP10 Q53GL7 1/20 0.40
LMNA P02545 1/20 0.40
GAA P10253 1/20 0.40
KMT2A Q03164 1/20 0.40
TLR4 O00206 1/20 0.39
TLR2 O60603 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21495038 1.00 LTA4H (0.46) LTA4HTSHRSRD5A2NR1H2BAX
SCHEMBL5738426 0.84 ACACB (0.50) MAOAACACBLMNAGAA
SCHEMBL5312161 0.84 PTGS1 (0.53) LTA4HTSHRLMNAGAAKMT2A
SCHEMBL5481298 0.83 SOS1 (0.42) LTA4HSOS1LMNA
SCHEMBL688950 0.81 CES2 (0.46) TSHRLMNAKMT2A
SCHEMBL3246785 0.78 ACP3 (0.44)
SCHEMBL7560598 0.78 LTA4H (0.52) LTA4HTSHRSRD5A2NR1H2BAX
SCHEMBL40530 0.78 HSPB1 (0.53) LTA4HSRD5A2CA1CA2CA9
SCHEMBL41221 0.78 LMNA (0.51) MAOAGSTP1CA1CA2CA9
SCHEMBL5738475 0.77 ALDH1A1 (0.49) LTA4HTSHRLMNAKMT2ATLR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2585459-A1 ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF Chiesi Farmaceutici S.p.A. (IT) 2013-05-01 EP disclosed
WO-2011161018-A1 ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF CHIESI FARMACEUTICI S.P.A. (IT) 2011-12-29 WO disclosed
EP-2265606-A1 HEPATITIS C VIRUS INHIBITORS Bristol-Myers Squibb Company (US) 2010-12-29 EP disclosed
WO-2009129109-A1 HEPATITIS C VIRUS INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2009-10-22 WO disclosed
WO-2007058504-A1 NOVEL COMPOUNDS AS AGONIST FOR PPAR GAMMA AND PPAR ALPHA, METHOD FOR PREPARATION OF THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME LG LIFE SCIENCES, LTD. (KR) 2007-05-24 WO disclosed
WO-2006057503-A1 NOVEL COMPOUNDS AS AGONIST FOR PPARϜ AND PPARα, METHOD FOR PREPARATION OF THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME LG LIFE SCIENCES, LTD. (KR) 2006-06-01 WO disclosed