SCHEMBL17030476

SCHEMBL17030476

CO[Si](CCCNC(=O)Nc1cccnc1)(OC)OC

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 1/20 0.72
FLT4 P35916 1/20 0.72
KEAP1 Q14145 2/20 0.58
NFE2L2 Q16236 2/20 0.58
KDM4E B2RXH2 2/20 0.58
L3MBTL1 Q9Y468 2/20 0.54
AHR P35869 1/20 0.54
RAB9A P51151 5/20 0.51
NPC1 O15118 4/20 0.51
MAPT P10636 1/20 0.51
PKM P14618 1/20 0.51
HSD17B10 Q99714 1/20 0.50
MEN1 O00255 1/20 0.50
CASP3 P42574 1/20 0.50
KMT2A Q03164 1/20 0.50
SENP8 Q96LD8 1/20 0.50
SENP7 Q9BQF6 1/20 0.50
SENP6 Q9GZR1 1/20 0.50
NOTUM Q6P988 1/20 0.49
FPR2 P25090 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16137613 0.87 CDK2 (0.69) CDK2FLT4KEAP1NFE2L2KDM4E
SCHEMBL17133246 0.85 LMNA (0.65) KDM4EL3MBTL1RAB9ANPC1KMT2A
SCHEMBL19822466 0.84 BCL6 (0.59) CDK2FLT4KDM4EMEN1KMT2A
SCHEMBL17030472 0.83 KEAP1 (0.54) CDK2FLT4KEAP1NFE2L2KDM4E
SCHEMBL12989334 0.83 CDK2 (0.81) CDK2FLT4KEAP1NFE2L2L3MBTL1
SCHEMBL20220960 0.82 CDK2 (0.62) CDK2FLT4KEAP1NFE2L2KDM4E
SCHEMBL3780409 0.81 FLT4 (0.81) CDK2FLT4KEAP1NFE2L2L3MBTL1
SCHEMBL28415484 0.81 LMNA (0.68) CDK2FLT4KDM4ERAB9ANPC1
SCHEMBL10987238 0.80 CDK2 (0.75) CDK2FLT4KEAP1NFE2L2KDM4E
SCHEMBL30831950 0.79 CDK2 (0.73) CDK2FLT4KEAP1NFE2L2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10954340-B2 Polyimide precursor composition TOKYO OHKA KOGYO CO., LTD. (JP) 2021-03-23 US disclosed
US-10696845-B2 Energy-sensitive resin composition TOKYO OHKA KOGYO CO., LTD. (JP) 2020-06-30 US disclosed
US-20190225804-A1 ENERGY-SENSITIVE RESIN COMPOSITION TOKYO OHKA KOGYO CO., LTD. (JP) 2019-07-25 US disclosed
EP-3330320-B1 POLYIMIDE PRECURSOR COMPOSITION TOKYO OHKA KOGYO CO LTD (JP) 2019-04-24 EP disclosed
US-20180223045-A1 POLYIMIDE PRECURSOR COMPOSITION TOKYO OHKA KOGYO CO., LTD. (JP) 2018-08-09 US disclosed
US-20180223045-A1 POLYIMIDE PRECURSOR COMPOSITION TOKYO OHKA KOGYO CO., LTD. (JP) 2018-08-09 US disclosed
US-10023540-B2 Hydrogen barrier agent, hydrogen barrier film forming composition, hydrogen barrier film, method for producing hydrogen barrier film, and electronic element TOKYO OHKA KOGYO CO., LTD. (JP) 2018-07-17 US disclosed
EP-3330320-A1 POLYIMIDE PRECURSOR COMPOSITION Tokyo Ohka Kogyo Co., Ltd. (JP) 2018-06-06 EP disclosed
US-9981914-B2 2018-05-29 US disclosed
US-20180086717-A1 HYDROGEN BARRIER AGENT, HYDROGEN BARRIER FILM FORMING COMPOSITION, HYDROGEN BARRIER FILM, METHOD FOR PRODUCING HYDROGEN BARRIER FILM, AND ELECTRONIC ELEMENT TOKYO OHKA KOGYO CO., LTD. (JP) 2018-03-29 US disclosed
WO-2017026448-A1 POLYIMIDE PRECURSOR COMPOSITION 東京応化工業株式会社 2017-02-16 WO disclosed
EP-2910611-B1 CARBON BLACK DISPERSION TOKYO OHKA KOGYO CO LTD (JP) 2016-12-07 EP disclosed
WO-2016158679-A1 ENERGY-SENSITIVE RESIN COMPOSITION 東京応化工業株式会社 2016-10-06 WO disclosed
EP-2910611-A1 Carbon black dispersion TOKYO OHKA KOGYO CO., LTD. (JP) 2015-08-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180086717-A1 HYDROGEN BARRIER AGENT, HYDROGEN BARRIER FILM FORMING COMPOSITION, HYDROGEN BARRIER FILM, METHOD FOR PRODUCING HYDROGEN BARRIER FILM, AND ELECTRONIC ELEMENT SLC9A2, SLC9A1, NHERF1 CDK2 4307/4885FLT4 4800/4885KEAP1 1894/4885
US-10023540-B2 Hydrogen barrier agent, hydrogen barrier film forming composition, hydrogen barrier film, method for producing hydrogen barrier film, and electronic element SLC9A2, SLC9A1, NHERF1 CDK2 4307/4885FLT4 4800/4885KEAP1 1894/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.