SCHEMBL1703281

SCHEMBL1703281

Cc1nc(Cl)nc(Cl)c1Cl

nearest known ligand 0.45

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.45
CYP1A2 P05177 1/20 0.40
ALDH1A1 P00352 2/20 0.39
ALOX15 P16050 1/20 0.39
TSHR P16473 1/20 0.39
KDM4E B2RXH2 1/20 0.31
RECQL P46063 1/20 0.31
IDO1 P14902 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1586662 0.84 ALDH1A1 (0.47) LMNACYP1A2ALDH1A1ALOX15TSHR
SCHEMBL218726 0.77 ALDH1A1 (0.54) CYP1A2ALDH1A1ALOX15TSHR
SCHEMBL801870 0.77 ALDH1A1 (0.39) CYP1A2ALDH1A1ALOX15TSHRMEN1
SCHEMBL10376639 0.77 LMNA (0.50) LMNAIDO1
SCHEMBL8733589 0.74 ALDH1A1 (0.61) CYP1A2ALDH1A1ALOX15TSHR
SCHEMBL7157400 0.73 LMNA (0.41) LMNATSHRKDM4EIDO1MEN1
SCHEMBL20421684 0.72 TLR8 (0.44) LMNACYP1A2ALDH1A1KDM4EIDO1
SCHEMBL3847571 0.72 ALDH1A1 (0.35) LMNAALDH1A1ALOX15TSHRKDM4E
SCHEMBL10043017 0.72 ALDH1A1 (0.35) ALDH1A1ALOX15TSHR
SCHEMBL16247844 0.72 ALDH1A1 (0.35) ALDH1A1ALOX15TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0004945-B1 PROCESS FOR THE PREPARATION OF 2.4-DIFLUORO-5-CHLORO-6-METHYLPYRIMIDINE BAYER AG (DE) 1982-03-03 EP claimed
US-12637458-B2 Imidazo[1,2-a]pyridine compounds and their use in therapy IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) 2026-05-26 US disclosed
US-20260092050-A1 CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF RAPT THERAPEUTICS INC (US) 2026-04-02 US disclosed
US-20250340532-A1 HETEROCYCLIC COMPOUND CCR4 INHIBITOR AND USER THEREOF XIZANG HAISCO PHARMACEUTICAL CO LTD (CN) 2025-11-06 US disclosed
US-12459922-B2 PARP7 inhibitors GILEAD SCIENCES, INC. (US) 2025-11-04 US disclosed
CN-120192324-A Heterocyclic compound, pharmaceutical composition and application 上海医药集团股份有限公司 2025-06-24 CN disclosed
EP-4534534-A1 HETEROCYCLIC COMPOUND CCR4 INHIBITOR AND USER THEREOF Xizang Haisco Pharmaceutical Co., Ltd. (CN) 2025-04-09 EP disclosed
CN-119707948-A Spiro heterocycle substituted pyrimidine compound and preparation method and application thereof 上海美悦生物科技发展有限公司 2025-03-28 CN disclosed
CN-119585256-A Chemokine receptor modulators and uses thereof 拉普特医疗公司 2025-03-07 CN disclosed
US-12240837-B2 Chemokine receptor modulators and uses thereof RAPT THERAPEUTICS, INC. (US) 2025-03-04 US disclosed
EP-0004945-A1 Process for the preparation of 2.4-Difluoro-5-chloro-6-methylpyrimidine BAYER AG (DE) 1979-10-31 EP disclosed
US-4141890-A FIBER-REACTIVE CIBA-GEIGY CORPORATION (US) 1979-02-27 US disclosed
US-RE29585-E DYEING WOOL CIBA-GEIGY CORPORATION (US) 1978-03-21 US disclosed
US-4067864-A FOR CELLULOSE OR POLYAMIDES CIBA-GEIGY AG (CH) 1978-01-10 US disclosed
US-4039523-A YELLOW CIBA-GEIGY AG (CH) 1977-08-02 US disclosed
US-4017477-A 3-Halogeno-6-hydroxy-pyridone-(2) azo dyestuffs CIBA-GEIGY AG (CH) 1977-04-12 US disclosed
US-4001205-A WATER-SOLUBLE, FIBER-REACTIVE PHENYLAZODIHYDROXY, METHYL, CYANOPYRIDINE DYESTUFFS CIBA-GEIGY AG (CH) 1977-01-04 US disclosed
US-4001203-A Heavy metal complexes of azo dyestuffs containing a heterocyclic diazo component and the residue of 5-halogeno-2,3-dihydrozypyridine as coupling component CIBA-GEIGY AG (CH) 1977-01-04 US disclosed
US-3971738-A Heavy metal complexes of azo compounds containing a halogeno-2,3-dihydroxy pyridine coupling component CIBA-GEIGY AG (CH) 1976-07-27 US disclosed
US-3956263-A 4-Methyl-2,6-dihydroxy-3-cyanopyridine containing dyestuffs CIBA-GEIGY AG (CH) 1976-05-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260092050-A1 CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF CCR1, CXCR2, CCR2 LMNA 3574/4885CYP1A2 3337/4885ALDH1A1 3882/4885
US-20250340532-A1 HETEROCYCLIC COMPOUND CCR4 INHIBITOR AND USER THEREOF CCR4, CCR1, CCR3 LMNA 4301/4885CYP1A2 1463/4885ALDH1A1 1894/4885
US-12459922-B2 PARP7 inhibitors PARP1, PARP11, PARP2 LMNA 1096/4885CYP1A2 2422/4885ALDH1A1 1171/4885
US-12240837-B2 Chemokine receptor modulators and uses thereof ACKR3, CCR5, CXCR3 LMNA 4823/4885CYP1A2 4297/4885ALDH1A1 2077/4885
US-12637458-B2 Imidazo[1,2-a]pyridine compounds and their use in therapy OGFR, CBR3, CBR1 LMNA 3941/4885CYP1A2 305/4885ALDH1A1 843/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.