Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | TPSAB1 | Q15661 | 6/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902875 | 0.90 | IGF1R (0.42) | — | |
| SCHEMBL902923 | 0.84 | NPC1 (0.36) | NPC1RAB9AMCHR1SCD5MAP3K12 | |
| SCHEMBL902789 | 0.81 | ALDH1A1 (0.42) | NPC1RAB9A | |
| SCHEMBL1705277 | 0.74 | JAK2 (0.44) | — | |
| SCHEMBL1704146 | 0.74 | NAMPT (0.43) | — | |
| SCHEMBL902745 | 0.67 | PLK4 (0.44) | NPC1RAB9A | |
| SCHEMBL1704634 | 0.66 | ALDH1A1 (0.38) | NPC1RAB9A | |
| SCHEMBL901929 | 0.66 | KARS1 (0.55) | MAP3K12 | |
| SCHEMBL1704967 | 0.64 | ALDH1A1 (0.44) | NPC1RAB9AMAP3K12 | |
| SCHEMBL901949 | 0.64 | KARS1 (0.48) | NPC1RAB9AMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |