Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 8/20 | 0.42 |
| ▸ | JAK3 | P52333 | 8/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704439 | 0.90 | NPC1 (0.36) | — | |
| SCHEMBL1705277 | 0.85 | JAK2 (0.44) | IGF1RJAK2JAK3PTK2NAMPT | |
| SCHEMBL902923 | 0.74 | NPC1 (0.36) | JAK2JAK3PTK2SYK | |
| SCHEMBL902789 | 0.74 | ALDH1A1 (0.42) | — | |
| SCHEMBL12354143 | 0.73 | GPR119 (0.55) | NAMPTHPGDS | |
| SCHEMBL29386809 | 0.73 | GPR119 (0.55) | NAMPTHPGDS | |
| SCHEMBL29118675 | 0.71 | GPR119 (0.47) | — | |
| SCHEMBL902272 | 0.70 | SYK (0.53) | WNT3ASYK | |
| SCHEMBL1704583 | 0.69 | ADORA2A (0.48) | JAK2JAK3PTK2ALK | |
| SCHEMBL30919531 | 0.69 | STS (0.46) | JAK2JAK3PTK2NAMPTHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |