Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.36 |
| ▸ | KARS1 | Q15046 | 3/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 4/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1705277 | 0.90 | JAK2 (0.44) | SYKJAK2JAK3PTK2KDM4E | |
| SCHEMBL1704439 | 0.84 | NPC1 (0.36) | NPC1RAB9AMCHR1SCD5MAP3K12 | |
| SCHEMBL1704829 | 0.83 | KARS1 (0.43) | NPC1RAB9AKARS1JAK2JAK3 | |
| SCHEMBL901929 | 0.81 | KARS1 (0.55) | KARS1SYKMAP3K12 | |
| SCHEMBL902774 | 0.79 | ALDH1A1 (0.37) | NPC1RAB9AKARS1KDM4EALDH1A1 | |
| SCHEMBL901665 | 0.79 | KARS1 (0.53) | KARS1SCD5MAP3K12 | |
| SCHEMBL901953 | 0.78 | KARS1 (0.56) | KARS1SYKMAP3K12 | |
| SCHEMBL902875 | 0.74 | IGF1R (0.42) | SYKJAK2JAK3PTK2 | |
| SCHEMBL902272 | 0.74 | SYK (0.53) | KARS1SYKMAP3K12 | |
| SCHEMBL901682 | 0.74 | ASIC3 (0.44) | NPC1MCHR1HSD11B1SCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |