Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAP3K12 | Q12852 | 6/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901343 | 0.89 | NAMPT (0.44) | CDK9 | |
| SCHEMBL1705014 | 0.88 | ALDH1A1 (0.44) | ALDH1A1KDM4EKDRCDK9SMN1; SMN2 | |
| SCHEMBL902789 | 0.84 | ALDH1A1 (0.42) | ALDH1A1KDM4ESMN1; SMN2KMT2ANPC1 | |
| SCHEMBL901312 | 0.83 | KARS1 (0.54) | ALDH1A1MAP3K12SMN1; SMN2JAK2KARS1 | |
| SCHEMBL901949 | 0.80 | KARS1 (0.48) | MAP3K12KDRMAP4K4ABL1LCK | |
| SCHEMBL1705140 | 0.79 | KDR (0.42) | MAP3K12KDRMAP4K4ABL1LCK | |
| SCHEMBL901340 | 0.79 | ALDH1A1 (0.50) | ALDH1A1KDM4ESMN1; SMN2KMT2ANPC1 | |
| SCHEMBL902803 | 0.78 | PDE10A (0.45) | CDK9 | |
| SCHEMBL1704146 | 0.75 | NAMPT (0.43) | ALDH1A1KDM4ECDK7 | |
| SCHEMBL901948 | 0.73 | KARS1 (0.46) | ALDH1A1KDM4ECDK9SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |