Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 8/20 | 0.45 |
| ▸ | GRM5 | P41594 | 7/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | LIPC | P11150 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704989 | 0.91 | NAMPT (0.44) | GRM1GRM5NAMPTPDK4JAK1 | |
| SCHEMBL1704634 | 0.91 | ALDH1A1 (0.38) | NAMPT | |
| SCHEMBL1704146 | 0.86 | NAMPT (0.43) | GRM1GRM5NAMPTPDK4JAK1 | |
| SCHEMBL1704352 | 0.84 | GRM1 (0.46) | GRM1GRM5NAMPTPDK4JAK1 | |
| SCHEMBL902774 | 0.82 | ALDH1A1 (0.37) | SOS1 | |
| SCHEMBL2811392 | 0.79 | PDK4 (0.60) | GRM1GRM5NAMPTPDK4 | |
| SCHEMBL902789 | 0.77 | ALDH1A1 (0.42) | SOS1 | |
| SCHEMBL1704197 | 0.77 | KARS1 (0.49) | GRM1GRM5NAMPTJAK1WNT3A | |
| SCHEMBL1705115 | 0.75 | KARS1 (0.55) | GRM1GRM5NAMPTJAK1WNT3A | |
| SCHEMBL1705279 | 0.75 | GRM1 (0.47) | GRM1GRM5NAMPTPDK4JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |