Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902803 | 0.88 | PDE10A (0.45) | NAMPTCDK9 | |
| SCHEMBL1704967 | 0.88 | ALDH1A1 (0.44) | ALDH1A1KDM4ESMN1; SMN2ALOX15TSHR | |
| SCHEMBL901948 | 0.85 | KARS1 (0.46) | ALDH1A1KDM4ESMN1; SMN2NAMPTALOX15 | |
| SCHEMBL1704842 | 0.83 | KARS1 (0.52) | ALDH1A1KDM4ESMN1; SMN2NAMPTALOX15 | |
| SCHEMBL902789 | 0.81 | ALDH1A1 (0.42) | ALDH1A1KDM4ESMN1; SMN2ALOX15TSHR | |
| SCHEMBL901769 | 0.80 | KARS1 (0.60) | ALDH1A1SMN1; SMN2NAMPTALOX15TSHR | |
| SCHEMBL901340 | 0.79 | ALDH1A1 (0.50) | ALDH1A1KDM4ESMN1; SMN2ALOX15TSHR | |
| SCHEMBL902213 | 0.78 | KARS1 (0.40) | KARS1CDK9KDR | |
| SCHEMBL901702 | 0.78 | KARS1 (0.51) | MAPK1KARS1LMNAFAAH | |
| SCHEMBL11963526 | 0.77 | KHK (0.39) | ALDH1A1KDM4ESMN1; SMN2NAMPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |