Biphenyl

Biphenyl

SCHEMBL1706263

O.O=S(=O)(O)c1ccccc1-c1ccccc1.c1ccc(-c2ccccc2)cc1

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 known ✓ P35354 1/20 0.42
HDAC4 known ✓ P56524 1/20 0.41
HDAC2 known ✓ Q92769 1/20 0.41
HDAC8 known ✓ Q9BY41 1/20 0.41
HDAC6 known ✓ Q9UBN7 1/20 0.41
MEN1 known ✓ O00255 1/20 0.38
THRB known ✓ P10828 1/20 0.38
SCN9A known ✓ Q15858 1/20 0.38
MMP1 known ✓ P03956 1/20 0.38
MMP8 known ✓ P22894 1/20 0.38
MMP13 known ✓ P45452 1/20 0.38
CASP1 P29466 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.43
TSHR P16473 1/20 0.43
AKR1B1 P15121 1/20 0.42
ALDH1A1 P00352 2/20 0.41
HPGD P15428 1/20 0.41
BCL2L1 Q07817 1/20 0.41
HSD17B10 Q99714 1/20 0.41
EDNRB P24530 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL27371066 0.98 CASP1 (0.46) CASP1SMN1; SMN2TSHRAKR1B1PTGS2
SCHEMBL8597480 0.96 PTGS2 (0.47) CASP1SMN1; SMN2TSHRAKR1B1PTGS2
SCHEMBL15849847 0.96 PTGS2 (0.47) CASP1SMN1; SMN2TSHRAKR1B1PTGS2
SCHEMBL232659 0.96 CASP1 (0.47) CASP1SMN1; SMN2TSHRAKR1B1PTGS2
SCHEMBL29743050 0.96 CASP1 (0.47) CASP1SMN1; SMN2TSHRAKR1B1PTGS2
Lithium SCHEMBL3173875 0.94 CASP1 (0.46) CASP1SMN1; SMN2TSHRAKR1B1PTGS2
SCHEMBL28934633 0.94 CASP1 (0.46) CASP1SMN1; SMN2TSHRAKR1B1PTGS2
SCHEMBL29194067 0.94 CASP1 (0.46) CASP1SMN1; SMN2TSHRAKR1B1PTGS2
Hydrochloric Acid SCHEMBL11757790 0.94 CASP1 (0.46) CASP1SMN1; SMN2TSHRAKR1B1PTGS2
SCHEMBL1870052 0.94 CASP1 (0.46) CASP1SMN1; SMN2TSHRAKR1B1PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4183841-A1 WATER-BASED INTUMESCENT ADHESIVE Wolman Wood and Fire Protection GmbH (DE) 2023-05-24 EP disclosed
EP-1932876-B1 Method for manufacturing polymer foams BASF SE (DE) 2012-04-18 EP disclosed
WO-2011069891-A1 METHOD FOR PRODUCING CHARGE-STRUCTURED COATINGS BASF SE (DE) 2011-06-16 WO disclosed
EP-0911358-B1 Foamable polyvinylhalide resin compositions, use of polymers therein as processing aids and mouldings obtained therefrom EVONIK ROEHM GMBH (DE) 2010-04-21 EP disclosed
EP-1682588-B1 METHOD FOR THE PRODUCTION OF POLYMER POWDERS FROM AQUEOUS POLYMER DISPERSIONS BASF SE (DE) 2009-05-27 EP disclosed
EP-1863866-B1 METHOD FOR PRODUCING POLYMER POWDERS BASF SE (DE) 2009-03-04 EP disclosed
EP-1932876-A2 Method for manufacturing polymer foams BASF SE (DE) 2008-06-18 EP disclosed
EP-1725609-B1 CARBODIIMIDES COMPRISING THIOCARBAMIDE ACID ESTER GROUPS BASF SE (DE) 2008-05-21 EP disclosed
EP-1664224-B1 TWO-COMPONENT STRUCTURAL ADHESIVE HAVING HIGH INITIAL ADHESION HENKEL KGAA (DE) 2008-05-21 EP disclosed
EP-1863866-A1 METHOD FOR PRODUCING POLYMER POWDERS BASF AKTIENGESELLSCHAFT (DE) 2007-12-12 EP disclosed
WO-1993025519-A1 COPOLYMERIZABLE OXIME ETHERS AND COPOLYMERS CONTAINING THEM BASF AKTIENGESELLSCHAFT (DE) 1993-12-23 WO disclosed
EP-0574803-A2 Use of aqueous dispersions as hot-melt adhesive BASF Aktiengesellschaft (DE) 1993-12-22 EP disclosed
EP-0530535-A2 Thermoplastic moulding masses with improved multiaxial toughness BASF Aktiengesellschaft (DE) 1993-03-10 EP disclosed
EP-0522306-A1 Room temperature curing aqueous synthetic resin composition and its use as laminating adhesive BASF Aktiengesellschaft (DE) 1993-01-13 EP disclosed
EP-0496121-A1 Impact-resistant moulding with high transparency BASF Aktiengesellschaft (DE) 1992-07-29 EP disclosed
EP-0495231-A2 Foamable polyvinylhalide resin compositions with improved processability BASF Aktiengesellschaft (DE) 1992-07-22 EP disclosed
EP-0484723-A2 PVC masses BASF Aktiengesellschaft (DE) 1992-05-13 EP disclosed
EP-0483529-A1 Impact resistant polyvinylchloride resin compositions BASF Aktiengesellschaft (DE) 1992-05-06 EP disclosed
EP-0465964-A1 Process for separation of volatile components from polymers prepared in emulsion BASF Aktiengesellschaft (DE) 1992-01-15 EP disclosed
EP-0452787-A1 Process for the prepration of a thermostable polyvinylhalide resin composition BASF Aktiengesellschaft (DE) 1991-10-23 EP disclosed