Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 4/20 | 0.33 |
| ▸ | BRAF | P15056 | 4/20 | 0.33 |
| ▸ | STAT6 | P42226 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1707901 | 0.86 | GAA (0.38) | GAAALOX15ALDH1A1MAPTMAPK1 | |
| SCHEMBL1708599 | 0.85 | WNT3A (0.38) | MAPTMTORRAF1BRAFRAB9A | |
| SCHEMBL1707989 | 0.85 | EED (0.38) | GAAALOX15ALDH1A1MAPTMAPK1 | |
| SCHEMBL1708222 | 0.83 | STAT6 (0.36) | GAAALOX15MAPK1MTORRAF1 | |
| SCHEMBL1708277 | 0.79 | RORC (0.33) | — | |
| SCHEMBL1707899 | 0.79 | FFAR1 (0.43) | GAAALDH1A1KDM4EHSD17B10TSHR | |
| SCHEMBL1708221 | 0.78 | INSR (0.34) | GAAALDH1A1MAPTKDM4ETSHR | |
| SCHEMBL10291552 | 0.77 | MAPT (0.37) | GAAALOX15ALDH1A1MAPTMAPK1 | |
| SCHEMBL1708225 | 0.75 | KLKB1 (0.35) | GAAALDH1A1MAPTPIK3CAMTOR | |
| SCHEMBL1708348 | 0.75 | GAA (0.39) | GAAALOX15ALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |