Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 3/20 | 0.34 |
| ▸ | RAF1 | P04049 | 2/20 | 0.34 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1707989 | 0.90 | EED (0.38) | MAPTBRAFRAF1EZH2MTOR | |
| SCHEMBL1708222 | 0.88 | STAT6 (0.36) | BRAFRAF1EZH2MTORAOC3 | |
| SCHEMBL3719582 | 0.87 | WNT3A (0.39) | WNT3APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1707923 | 0.85 | GAA (0.36) | MAPTRAB9ABRAFRAF1MTOR | |
| SCHEMBL1708225 | 0.84 | KLKB1 (0.35) | MAPTRAB9AEZH2MTOR | |
| SCHEMBL13047215 | 0.80 | FFAR1 (0.41) | WNT3APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10010507 | 0.80 | FFAR1 (0.47) | WNT3APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1708221 | 0.76 | INSR (0.34) | MAPT | |
| SCHEMBL3714484 | 0.76 | WNT3A (0.38) | WNT3APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1708457 | 0.75 | STAT6 (0.37) | MAPTBRAFRAF1EZH2MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |