Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HBB | P68871 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708596 | 0.85 | INSR (0.35) | INSRIGF1RMAPTALDH1A1GAA | |
| SCHEMBL1708594 | 0.78 | FFAR1 (0.46) | — | |
| SCHEMBL1707923 | 0.78 | GAA (0.36) | MAPTALDH1A1GAAKDM4ETDP1 | |
| SCHEMBL1708225 | 0.77 | KLKB1 (0.35) | MAPTALDH1A1GAASMN1; SMN2TDP1 | |
| SCHEMBL1707989 | 0.76 | EED (0.38) | MAPTALDH1A1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL1708599 | 0.76 | WNT3A (0.38) | MAPT | |
| SCHEMBL1708277 | 0.76 | RORC (0.33) | — | |
| SCHEMBL10291227 | 0.75 | FFAR1 (0.37) | MAPTALDH1A1GAAKDM4EMEN1 | |
| SCHEMBL1708592 | 0.75 | ALDH1A1 (0.33) | ALDH1A1GAASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL1708222 | 0.74 | STAT6 (0.36) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |