Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17109235 | 0.93 | RBP4 (0.43) | RBP4SMN1; SMN2KDM4EMAPTTHRB | |
| SCHEMBL17690473 | 0.81 | PRKAA2 (0.53) | RBP4MAPTTHRB | |
| SCHEMBL17092664 | 0.79 | PIK3CA (0.51) | — | |
| SCHEMBL2589502 | 0.77 | PDE4B (0.47) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL17092666 | 0.76 | HRH4 (0.50) | RBP4KDM4EMAPTTHRBNAMPT | |
| SCHEMBL17109236 | 0.74 | PRKAA2 (0.54) | MAPTTHRB | |
| SCHEMBL14695355 | 0.73 | GPR119 (0.58) | GPR119DYRK1A | |
| SCHEMBL25914622 | 0.72 | UBE2M (0.40) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL16306693 | 0.72 | RAB9A (0.49) | RBP4SMN1; SMN2DYRK1AALDH1A1HPGD | |
| SCHEMBL12354084 | 0.72 | HPGD (0.52) | RBP4SMN1; SMN2DYRK1AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3009424-B1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | ASTELLAS PHARMA INC (JP) | 2017-12-20 | — | — | EP | disclosed |
| EP-3009424-B1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | ASTELLAS PHARMA INC (JP) | 2017-12-20 | — | — | EP | disclosed |
| US-9428501-B2 | Bicyclic nitrogen-containing aromatic heterocyclic amide compound | ASTELLAS PHARMA INC. (JP) | 2016-08-30 | — | — | US | disclosed |
| US-9428501-B2 | Bicyclic nitrogen-containing aromatic heterocyclic amide compound | ASTELLAS PHARMA INC. (JP) | 2016-08-30 | — | — | US | disclosed |
| US-9428501-B2 | Bicyclic nitrogen-containing aromatic heterocyclic amide compound | ASTELLAS PHARMA INC. (JP) | 2016-08-30 | — | — | US | disclosed |
| EP-3009424-A1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2016-04-20 | — | — | EP | disclosed |
| EP-3009424-A1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2016-04-20 | — | — | EP | disclosed |
| US-20150266869-A1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2015-09-24 | — | — | US | disclosed |
| US-20150266869-A1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2015-09-24 | — | — | US | disclosed |
| US-20150266869-A1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2015-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266869-A1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | PIK3CA, SLC16A3, MCTS1 | RBP4 3774/4885SMN1; SMN2 4018/4885KDM4E 399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.