SCHEMBL1709459

SCHEMBL1709459

O=C(O)CC1CCCC(N(CC2CCCCC2)CC2CCCCC2)C1c1ccc(Cl)c(F)c1

nearest known ligand 0.35

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CXCR3 P49682 12/20 0.34
SLC6A4 P31645 2/20 0.32
PTGIR P43119 1/20 0.32
PTGDR Q13258 1/20 0.32
SLC6A3 Q01959 1/20 0.32
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
FFAR4 Q5NUL3 1/20 0.32
SLC6A2 P23975 1/20 0.32
PKM P14618 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1709358 0.92 DPEP1 (0.36) SLC6A4PTGIRNPC1RAB9ASLC6A2
SCHEMBL1709359 0.91 USP30 (0.38) SLC6A4NPC1RAB9ASLC6A2PKM
SCHEMBL1709448 0.88 FFAR4 (0.32) CXCR3FFAR4SLC6A2
SCHEMBL1709480 0.85 NPC1 (0.38) NPC1RAB9A
SCHEMBL1709409 0.85 POLB (0.38) SLC6A4RAB9ASLC6A2PKM
SCHEMBL1709454 0.84 SLC6A2 (0.40) SLC6A4SLC6A3FFAR4SLC6A2PKM
SCHEMBL1709408 0.84 DGAT1 (0.38)
SCHEMBL1709481 0.83 MDM2 (0.43) SLC6A4SLC6A3SLC6A2
SCHEMBL1709489 0.83 OPRM1 (0.37) SLC6A4SLC6A2PKM
SCHEMBL10033118 0.82 OPRL1 (0.38) PTGDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012046771-A1 CYCLOALKANE COMPOUND アステラス製薬株式会社 (JP) 2012-04-12 WO disclosed