Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6131935 | 0.89 | DHODH (0.49) | DHODHKMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL1334088 | 0.84 | DHODH (0.53) | DHODHKMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL9898507 | 0.83 | NR4A2 (0.50) | KMT2AMAPTMEN1KDM4EALDH1A1 | |
| SCHEMBL6170807 | 0.83 | LMNA (0.50) | KMT2AMAPTMEN1KDM4EALDH1A1 | |
| SCHEMBL30128969 | 0.81 | DHODH (0.46) | DHODHKMT2AMAPTMEN1KDM4E | |
| SCHEMBL1334120 | 0.81 | DHODH (0.46) | DHODHKMT2AMAPTMEN1KDM4E | |
| SCHEMBL1959313 | 0.80 | LMNA (0.46) | KMT2AMAPTMEN1KDM4EALDH1A1 | |
| SCHEMBL9861231 | 0.79 | SLC10A2 (0.52) | DHODHKMT2AMAPTMEN1KDM4E | |
| SCHEMBL9860541 | 0.77 | TUBB4A (0.54) | KMT2AMAPTMEN1ALDH1A1HPGD | |
| SCHEMBL6818270 | 0.77 | ALDH1A1 (0.50) | DHODHKMT2AMAPTMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606274-B9 | INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS, NAPHTHOLS AND PHOTOCHROMIC ARTICLES | TRANSITIONS OPTICAL INC (US) | 2019-01-16 | — | — | EP | disclosed |
| EP-1606274-B1 | INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS, NAPHTHOLS AND PHOTOCHROMIC ARTICLES | TRANSITIONS OPTICAL INC (US) | 2018-08-08 | — | — | EP | disclosed |
| EP-2345648-B1 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL INC (US) | 2012-10-24 | — | — | EP | disclosed |
| EP-2345648-A1 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL, INC. (US) | 2011-07-20 | — | — | EP | disclosed |
| EP-2345647-A2 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL, INC. (US) | 2011-07-20 | — | — | EP | disclosed |
| US-7557208-B2 | Naphthols useful for preparing indeno-fused photochromic naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2009-07-07 | — | — | US | disclosed |
| US-7517982-B2 | Naphthols useful for preparing indeno-fused photochromic naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2009-04-14 | — | — | US | disclosed |
| US-20090062533-A1 | NAPHTHOLS USEFUL FOR PREPARING INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2009-03-05 | — | — | US | disclosed |
| US-7262295-B2 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-20070155964-A1 | Naphthols useful for preparing indeno-fused photochromic naphthopyrans | TRANSITIONS OPTICAL LIMITED (IE) | 2007-07-05 | — | — | US | disclosed |
| EP-1606274-A1 | INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS, NAPHTHOLS AND PHOTOCHROMIC ARTICLES | TRANSITIONS OPTICAL, INC. (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2005090327-A1 | INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS, NAPHTHOLS AND PHOTOCHROMIC ARTICLES | TRANSITIONS OPTICAL, INC. (US) | 2005-09-29 | — | — | WO | disclosed |
| EP-1214310-B1 | NOVEL PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2005-04-27 | — | — | EP | disclosed |
| US-20040185255-A1 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | TRANSITIONS OPTICAL LIMITED (IE) | 2004-09-23 | — | — | US | disclosed |
| EP-1214311-B1 | NOVEL INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2004-09-15 | — | — | EP | disclosed |
| EP-1214310-A1 | NOVEL PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2002-06-19 | — | — | EP | disclosed |
| US-6348604-B1 | COMPOUNDS IN WHICH SELECTION AND PLACEMENT OF SUBSTITUENTS CONTROL WAVELENGTH AND/OR INTENSITY OF VISIBLE ABSORBANCE BANDS | PPG INDUSTRIES OHIO, INC. | 2002-02-19 | — | — | US | disclosed |
| US-6296785-B1 | OPHTHALMIC AND CONTACT LENSES; WINDOWS, SAFETY GLASS FOR CARS | PPG INDUSTRIES OHIO, INC. | 2001-10-02 | — | — | US | disclosed |
| WO-2001019812-A1 | NOVEL PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2001-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040185255-A1 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles | IPO4, NPM1, PPOX | DHODH 187/4885KMT2A 2129/4885MAPT 1550/4885 |
| US-20070155964-A1 | Naphthols useful for preparing indeno-fused photochromic naphthopyrans | IPO5, IPO4, NQO1 | DHODH 622/4885KMT2A 3739/4885MAPT 970/4885 |
| US-20090062533-A1 | NAPHTHOLS USEFUL FOR PREPARING INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS | IPO5, IPO4, NQO1 | DHODH 622/4885KMT2A 3739/4885MAPT 970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.