Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170807 | 0.87 | LMNA (0.50) | LMNATSHRKDM4EKMT2AMEN1 | |
| SCHEMBL9898507 | 0.84 | NR4A2 (0.50) | LMNATSHRKDM4ESLC6A3KMT2A | |
| SCHEMBL1711290 | 0.80 | DHODH (0.56) | LMNATSHRKDM4EKMT2AMEN1 | |
| SCHEMBL12424592 | 0.77 | TSHR (0.46) | LMNATSHRKDM4ESLC6A4SLC6A3 | |
| SCHEMBL1791233 | 0.77 | KDM4E (0.66) | LMNATSHRKDM4EKMT2AMEN1 | |
| SCHEMBL6171157 | 0.77 | PLA2G2A (0.49) | LMNATSHRKDM4EKMT2AMEN1 | |
| SCHEMBL12424591 | 0.76 | EGFR (0.47) | LMNATSHRKDM4ESLC6A4SLC6A3 | |
| SCHEMBL2470133 | 0.75 | LMNA (0.55) | LMNATSHRKDM4EKMT2AMEN1 | |
| SCHEMBL28283410 | 0.74 | LMNA (0.53) | LMNATSHRKDM4EKMT2AMEN1 | |
| SCHEMBL30128969 | 0.73 | DHODH (0.46) | LMNATSHRKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107253943-B | Photochromic compounds and compositions | 光学转变公司 | 2022-05-17 | — | — | CN | disclosed |
| EP-2651912-B1 | PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS | TRANSITIONS OPTICAL INC (US) | 2018-10-03 | — | — | EP | disclosed |
| CN-107253943-A | Photochromic compound and composition | 光学转变公司 | 2017-10-17 | — | — | CN | disclosed |
| EP-2651913-B1 | INDENO-FUSED RING COMPOUNDS HAVING PHOTOCHROMIC PROPERTIES | TRANSITIONS OPTICAL INC (US) | 2017-04-19 | — | — | EP | disclosed |
| US-9309455-B2 | Indeno-fused ring compounds | TRANSITIONS OPTICAL, INC. (US) | 2016-04-12 | — | — | US | disclosed |
| US-9034219-B2 | Photochromic compounds and compositions | TRANSITIONS OPTICAL, INC. (US) | 2015-05-19 | — | — | US | disclosed |
| US-20140166948-A1 | INDENO-FUSED RING COMPOUNDS | TRANSITIONS OPTICAL LIMITED (IE) | 2014-06-19 | — | — | US | disclosed |
| US-8698117-B2 | Indeno-fused ring compounds | TRANSITIONS OPTICAL, INC. (US) | 2014-04-15 | — | — | US | disclosed |
| EP-2651913-A1 | INDENO- FUSED RING COMPOUNDS HAVING PHOTOCHROMIC PROPERTIES | Transitions Optical, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| EP-2651912-A1 | PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS | Transitions Optical, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| CN-103354810-A | Photochromic compounds and compositions | TRANSITIONS OPTICAL INC | 2013-10-16 | — | — | CN | disclosed |
| WO-2013032608-A1 | INDENO-FUSED RING COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2013-03-07 | — | — | WO | disclosed |
| US-20120156521-A1 | PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS | TRANSITIONS OPTICAL, INC. (US) | 2012-06-21 | — | — | US | disclosed |
| WO-2012082506-A1 | PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS | TRANSITIONS OPTICAL, INC. (US) | 2012-06-21 | — | — | WO | disclosed |
| WO-2012082381-A1 | INDENO- FUSED RING COMPOUNDS HAVING PHOTOCHROMIC PROPERTIES | TRANSITIONS OPTICAL, INC. (US) | 2012-06-21 | — | — | WO | disclosed |
| US-20120126185-A1 | INDENO-FUSED RING COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2012-05-24 | — | — | US | disclosed |
| US-20110140056-A1 | Indeno-fused ring compounds | TRANSITIONS OPTICAL, INC. (US) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120156521-A1 | PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS | CRY2, CRY1, PPOX | LMNA 657/4885TSHR 4783/4885KDM4E 2937/4885 |
| US-20110140056-A1 | Indeno-fused ring compounds | CRY2, SQOR, INTS6 | LMNA 1680/4885TSHR 3550/4885KDM4E 464/4885 |
| US-20120126185-A1 | INDENO-FUSED RING COMPOUNDS | CRY2, SQOR, INTS6 | LMNA 1680/4885TSHR 3550/4885KDM4E 464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.