Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHKA | P35790 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 5/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | CCR4 | P51679 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25255269 | 0.86 | CCR4 (0.41) | MAPTSMN1; SMN2KMT2ARAB9ACCR4 | |
| SCHEMBL17115259 | 0.77 | ROCK2 (0.50) | ROCK2MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL17115265 | 0.73 | IDO1 (0.43) | ROCK2MAPTSMN1; SMN2KMT2ANPC1 | |
| SCHEMBL19257440 | 0.72 | EGFR (0.41) | MAPTCHRM5CHKASMN1; SMN2KMT2A | |
| SCHEMBL22373976 | 0.69 | TDO2 (0.50) | ROCK2SMN1; SMN2NPC1RAB9ATDO2 | |
| SCHEMBL4401625 | 0.69 | TNKS (0.47) | MAPTSMN1; SMN2KMT2ANPC1RAB9A | |
| SCHEMBL11885001 | 0.69 | IDO1 (0.46) | ROCK2TDO2IDO1 | |
| SCHEMBL840516 | 0.69 | KDM4E (0.48) | MAPTSMN1; SMN2KMT2ANPC1RAB9A | |
| SCHEMBL25477519 | 0.69 | ROCK2 (0.43) | ROCK2MAPTKMT2ANPC1RAB9A | |
| SCHEMBL25476961 | 0.69 | ROCK2 (0.40) | ROCK2MAPTSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170183356-A1 | New Imaging Agents and Methods of Identifying Same | THR TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-06-29 | — | — | US | disclosed |
| US-20170183356-A1 | New Imaging Agents and Methods of Identifying Same | THR TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-06-29 | — | — | US | disclosed |
| WO-2015143349-A1 | NEW IMAGING AGENTS AND METHODS OF IDENTIFYING SAME | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170183356-A1 | New Imaging Agents and Methods of Identifying Same | DDX3X, DDX21, DAXX | ROCK2 277/4885MAPT 2313/4885CHRM5 4605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.