SCHEMBL840516

SCHEMBL840516

CN(C)c1ccc2c(=O)c3ccc(N(C)C)cc3oc2c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.48
CCR4 P51679 1/20 0.48
QPCT Q16769 1/20 0.45
IGLV6-57 P01721 2/20 0.45
SLC16A3 O15427 1/20 0.45
MAOA P21397 3/20 0.45
NPC1 O15118 2/20 0.45
RAB9A P51151 1/20 0.45
ALDH1A1 P00352 4/20 0.43
GLA P06280 3/20 0.43
CYP3A4 P08684 3/20 0.43
HPGD P15428 3/20 0.43
MAPT P10636 3/20 0.43
CASP1 P29466 2/20 0.43
CASP7 P55210 2/20 0.43
HSD17B10 Q99714 2/20 0.43
PGAM1 P18669 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
L3MBTL1 Q9Y468 2/20 0.42
MAPK1 P28482 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30352933 1.00 KDM4E (0.48) KDM4ECCR4QPCTIGLV6-57SLC16A3
SCHEMBL12727717 0.91 CCR4 (0.46) KDM4ECCR4QPCTIGLV6-57SLC16A3
SCHEMBL9351374 0.91 MAOA (0.60) KDM4EMAOANPC1RAB9AALDH1A1
SCHEMBL27883920 0.90 APP (0.46) KDM4ECCR4QPCTIGLV6-57SLC16A3
SCHEMBL2440711 0.90 RAB9A (0.51) KDM4ECCR4QPCTIGLV6-57SLC16A3
SCHEMBL24403749 0.87 NPC1 (0.55) KDM4EMAOANPC1RAB9AALDH1A1
SCHEMBL18019300 0.87 SLC18A1 (0.45) KDM4ECCR4QPCTIGLV6-57SLC16A3
SCHEMBL12298172 0.84 MAPT (0.54) KDM4ECCR4NPC1RAB9AALDH1A1
SCHEMBL24895938 0.82 CCR4 (0.40) KDM4ECCR4QPCTIGLV6-57SLC16A3
SCHEMBL23116591 0.80 ALDH1A1 (0.41) KDM4ECCR4QPCTIGLV6-57SLC16A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11560365-B2 Non-fluorescent rhodamines THE UNIVERSITY OF TOKYO (JP) 2023-01-24 US disclosed
WO-2023284968-A1 CAGING-GROUP-FREE PHOTOACTIVATABLE FLUORESCENT DYES AND THEIR USE Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. (DE) 2023-01-19 WO disclosed
US-20210101915-A1 NEAR-IR GLUCOSE SENSORS PROFUSA, INC. (US) 2021-04-08 US disclosed
US-20210087160-A1 NOVEL NON-FLUORESCENT RHODAMINES THE UNIVERSITY OF TOKYO (JP) 2021-03-25 US disclosed
US-20210041465-A1 FLUOROGENIC PH SENSITIVE DYES AND THEIR METHOD OF USE Life Technologies Corporation 2021-02-11 US disclosed
US-10845373-B2 Fluorogenic pH sensitive dyes and their method of use Life Technologies Corporation (US) 2020-11-24 US disclosed
US-10717751-B2 Near-IR glucose sensors PROFUSA, INC. (US) 2020-07-21 US disclosed
WO-2018125913-A1 NEAR-IR GLUCOSE SENSORS PROFUSA, INC. (US) 2018-07-05 WO disclosed
US-20180179233-A1 NEAR-IR GLUCOSE SENSORS PROFUSA, INC. (US) 2018-06-28 US disclosed
US-20180179233-A1 NEAR-IR GLUCOSE SENSORS PROFUSA, INC. (US) 2018-06-28 US disclosed
US-20080274907-A1 FLUOROGENIC PH SENSITIVE DYES AND THEIR METHOD OF USE INVITROGEN CORPORATION (US) 2008-11-06 US disclosed
US-20080249321-A1 Fluorescent Probes Nagano, Tetsuo (JP) 2008-10-09 US disclosed
US-20080249321-A1 Fluorescent Probes Nagano, Tetsuo (JP) 2008-10-09 US disclosed
WO-2008076524-A2 FLUOROGENIC PH SENSITIVE DYES AND THEIR METHOD OF USE Life Technologies Corporation (US) 2008-06-26 WO disclosed
US-20070238884-A1 Fluorescent Dyes and Complexes CAMBRIDGE ENTERPRISE LIMITED (GB) 2007-10-11 US disclosed
US-20070238884-A1 Fluorescent Dyes and Complexes CAMBRIDGE ENTERPRISE LIMITED (GB) 2007-10-11 US disclosed
EP-1731898-A1 FLUORESCENT PROBES Nagano, Tetsuo (JP) 2006-12-13 EP disclosed
EP-0314480-B1 Fluorescent indicator dyes for calcium working at long wavelengths UNIV CALIFORNIA (US) 1994-09-14 EP disclosed
US-5049673-A Fluorescent indicator dyes for calcium working at long wavelengths THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1991-09-17 US disclosed
EP-0314480-A2 Fluorescent indicator dyes for calcium working at long wavelengths THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1989-05-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070238884-A1 Fluorescent Dyes and Complexes F12, PYM1, ANXA6 KDM4E 2807/4885CCR4 739/4885QPCT 2537/4885
US-20210101915-A1 NEAR-IR GLUCOSE SENSORS IRS1, INSR, SLC2A4 KDM4E 3160/4885CCR4 3699/4885QPCT 1515/4885
US-20210087160-A1 NOVEL NON-FLUORESCENT RHODAMINES QTRT1, QTRT2, NONO KDM4E 3057/4885CCR4 2950/4885QPCT 841/4885
US-20080274907-A1 FLUOROGENIC PH SENSITIVE DYES AND THEIR METHOD OF USE SLC11A2, MAN2B1, CD47 KDM4E 3702/4885CCR4 2389/4885QPCT 2397/4885
US-10845373-B2 Fluorogenic pH sensitive dyes and their method of use SLC11A2, MAN2B1, CD47 KDM4E 3702/4885CCR4 2389/4885QPCT 2397/4885
US-20180179233-A1 NEAR-IR GLUCOSE SENSORS IRS1, INSR, SLC2A4 KDM4E 3160/4885CCR4 3699/4885QPCT 1515/4885
US-20210041465-A1 FLUOROGENIC PH SENSITIVE DYES AND THEIR METHOD OF USE SLC11A2, MAN2B1, CD47 KDM4E 3702/4885CCR4 2389/4885QPCT 2397/4885
US-10717751-B2 Near-IR glucose sensors IRS1, G6PD, SLC2A8 KDM4E 1515/4885CCR4 4343/4885QPCT 1015/4885
US-11560365-B2 Non-fluorescent rhodamines QTRT1, QTRT2, NONO KDM4E 3402/4885CCR4 2946/4885QPCT 821/4885
US-20080249321-A1 Fluorescent Probes CBR3, CBR1, SQOR KDM4E 3941/4885CCR4 2650/4885QPCT 2494/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.