SCHEMBL17129795

SCHEMBL17129795

Cc1ccc(OS(=O)(=O)F)cn1

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.44
MAPT P10636 2/20 0.39
PTGS2 P35354 2/20 0.36
CHRNB2 P17787 4/20 0.36
CHRNA4 P43681 4/20 0.36
CHRNB1 P11230 1/20 0.36
CHRNB4 P30926 1/20 0.36
CHRNA3 P32297 1/20 0.36
CHRNB3 Q05901 1/20 0.36
GRM5 P41594 1/20 0.36
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA9 Q16790 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL752015 0.81 CXCR2 (0.39) KMT2AMAPTPTGS2CA1CA2
SCHEMBL18256810 0.80 KMT2A (0.39) KMT2AMAPTPTGS2CHRNB2CHRNA4
SCHEMBL27392770 0.80 ELANE (0.34) CA2CA9HDAC6
SCHEMBL27781618 0.79 KMT2A (0.44) KMT2AMAPTCHRNB2CHRNA4CHRNB1
SCHEMBL32665062 0.78 GPR119 (0.40) MAPTPTGS2CA1CA2CA9
SCHEMBL22852596 0.78 NNMT (0.42) KMT2ACHRNB2CHRNA4CA1CA2
SCHEMBL32665413 0.77 CA2 (0.34) CA1CA2CA9
SCHEMBL8564373 0.75 TDP1 (0.53) MAPTCA2
SCHEMBL10684102 0.75 MEN1 (0.49) KMT2AMAPTCA2
SCHEMBL17318128 0.73 CA2 (0.52) CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12390424-B2 Sulfur (VI) fluoride compounds and methods for the preparation thereof THE SCRIPPS RESEARCH INSTITUTE (US) 2025-08-19 US disclosed
CN-111689929-B Sulfur fluoride (VI) compound and preparation method thereof 斯克里普斯研究所 2024-05-31 CN disclosed
EP-4295841-A2 SULFUR (VI) FLUORIDE COMPOUNDS AND THEIR USE IN CLICK-REACTION The Scripps Research Institute (US) 2023-12-27 EP disclosed
EP-3892610-B1 SULFUR (VI) FLUORIDE COMPOUNDS AND THEIR USE IN CLICK-REACTION SCRIPPS RESEARCH INST (US) 2023-08-16 EP disclosed
US-20220313624-A1 SULFUR (VI) FLUORIDE COMPOUNDS AND METHODS FOR THE PREPARATION THEREOF THE SCRIPPS RESEARCH INSTITUTE (US) 2022-10-06 US disclosed
US-20220000799-A1 SULFUR (VI) FLUORIDE COMPOUNDS AND METHODS FOR THE PREPARATION THEREOF THE SCRIPPS RESEARCH INSTITUTE (US) 2022-01-06 US disclosed
EP-3892610-A1 SULFUR (VI) FLUORIDE COMPOUNDS AND THEIR USE AS SCREENING AGENT The Scripps Research Institute (US) 2021-10-13 EP disclosed
US-11141385-B2 Sulfur (VI) fluoride compounds and methods for the preparation thereof THE SCRIPPS RESEARCH INSTITUTE (US) 2021-10-12 US disclosed
EP-3151817-B1 SULFUR(VI) FLUORIDE COMPOUNDS AND METHODS FOR THE PREPARATION THEREOF SCRIPPS RESEARCH INST (US) 2021-03-03 EP disclosed
US-10913696-B2 Method for aromatic fluorination DOW GLOBAL TECHNOLOGIES LLC (US) 2021-02-09 US disclosed
US-20170210695-A1 METHOD FOR COUPLING A FIRST COMPOUND TO A SECOND COMPOUND DOW AGROSCIENCES LLC 2017-07-27 US disclosed
US-20170210695-A1 METHOD FOR COUPLING A FIRST COMPOUND TO A SECOND COMPOUND DOW AGROSCIENCES LLC 2017-07-27 US disclosed
US-20170196985-A1 SULFUR(VI) FLUORIDE COMPOUNDS AND METHODS FOR THE PREPARATION THEREOF THE SCRIPPS RESEARCH INSTITUTE 2017-07-13 US disclosed
US-20170174582-A1 METHOD FOR COUPLING A FIRST AROMATIC COMPOUND TO A SECOND AROMATIC COMPOUND DOW AGROSCIENCES LLC 2017-06-22 US disclosed
US-20170174582-A1 METHOD FOR COUPLING A FIRST AROMATIC COMPOUND TO A SECOND AROMATIC COMPOUND DOW AGROSCIENCES LLC 2017-06-22 US disclosed
EP-3151817-A1 SULFUR(VI) FLUORIDE COMPOUNDS AND METHODS FOR THE PREPARATION THEREOF The Scripps Research Institute (US) 2017-04-12 EP disclosed
WO-2016057770-A1 METHOD FOR COUPLING A FLUOROSULFONATE COMPOUND WITH AN AMINE COMPOUND DOW GLOBAL TECHNOLOGIES LLC (US) 2016-04-14 WO disclosed
WO-2016057771-A1 METHOD FOR COUPLING A FIRST COMPOUND TO A SECOND COMPOUND DOW GLOBAL TECHNOLOGIES LLC (US) 2016-04-14 WO disclosed
WO-2015188120-A1 SULFUR(VI) FLUORIDE COMPOUNDS AND METHODS FOR THE PREPARATION THEREOF THE SCRIPPS RESEARCH INSTITUTE (US) 2015-12-10 WO disclosed
WO-2015148931-A1 METHOD FOR COUPLING A FIRST AROMATIC COMPOUND TO A SECOND AROMATIC COMPOUND DOW GLOBAL TECHNOLOGIES LLC (US) 2015-10-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170196985-A1 SULFUR(VI) FLUORIDE COMPOUNDS AND METHODS FOR THE PREPARATION THEREOF CYP2F1, NAF1, CYP2S1 KMT2A 2082/4885MAPT 4164/4885PTGS2 4034/4885
US-12390424-B2 Sulfur (VI) fluoride compounds and methods for the preparation thereof GRB2, SCTR, OGFR KMT2A 3250/4885MAPT 4801/4885PTGS2 4213/4885
US-20170174582-A1 METHOD FOR COUPLING A FIRST AROMATIC COMPOUND TO A SECOND AROMATIC COMPOUND PAH, TYR, AHR KMT2A 319/4885MAPT 2958/4885PTGS2 4656/4885
US-10913696-B2 Method for aromatic fluorination ARSA, AHR, AR KMT2A 1036/4885MAPT 4157/4885PTGS2 4241/4885
US-20220313624-A1 SULFUR (VI) FLUORIDE COMPOUNDS AND METHODS FOR THE PREPARATION THEREOF QSOX1, YBX1, SFXN1 KMT2A 1800/4885MAPT 3482/4885PTGS2 4745/4885
US-20220000799-A1 SULFUR (VI) FLUORIDE COMPOUNDS AND METHODS FOR THE PREPARATION THEREOF PTMS, IGF2R, SCTR KMT2A 3438/4885MAPT 3607/4885PTGS2 4471/4885
US-20170210695-A1 METHOD FOR COUPLING A FIRST COMPOUND TO A SECOND COMPOUND PAICS, NUDT21, TIAL1 KMT2A 328/4885MAPT 4182/4885PTGS2 2291/4885
US-11141385-B2 Sulfur (VI) fluoride compounds and methods for the preparation thereof CYP2F1, CYP2S1, NAF1 KMT2A 2325/4885MAPT 4173/4885PTGS2 4051/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.